Asian-Australasian Journal of Animal Sciences

  • 제21권5호
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  • Pages.754-768
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  • 2008
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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DOI QR코드

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Growth Hormone Signaling in the Regulation of Acid Labile Subunit

  • Kim, Jin Wook (Department of Animal Science, College of Agriculture and Life Sciences, Cornell University) ;
  • Boisclair, Yves R. (Division of Applied Life Sciences (Institute of Agriculture and Life Science), College of Agriculture and Life Sciences Gyeongsang National University)
  • 투고 : 2007.09.05
  • 심사 : 2007.11.12
  • 발행 : 2008.05.01
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초록

The past decades have seen enormous advances in our understanding of how GH acts. GH is a pituitary-derived polypeptide hormone that has diverse physiological effects including the regulation of bone growth, carbohydrate and lipid metabolism. The effects of GH are mediated directly and indirectly through IGF-I. In addition, GH stimulates the hepatic production of ALS. In postnatal life, IGF-I and -II circulate as 150 kDa ternary complexes consisting of one molecule each of IGFBP-3 or IGFBP-5, IGF-I or IGF-II and ALS. It is now known that ALS increases significantly the half-lives of the IGFs, IGFBP-3 and -5, and therefore is responsible for maintaining a circulating reservoir for each of these proteins.

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참고문헌

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  1. The Endocrine Regulation of Chicken Growth vol.23, pp.12, 2010, https://doi.org/10.5713/ajas.2010.10329