Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
권호 표지

Effects of Gal geun (Puerariae Radix) on lowering lipid and antioxidant

  • Lee, Eun (College of life science and natural resources, Sangji University) ;
  • Kang, Jin-Ho (College of life science and natural resources, Sangji University)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Effects of Gal geun (Puerariae Radix) EtOH ext. on lipid lowering and antioxidant were investigated in hyperlipidemic rat. Concentration of FFA and triglyceride in plasma showed a tendency to decrease in Gal geun ext. groups. Concentration of plasma total cholesterol and LDL-cholesterol decreased in Gal geun ext. groups. However the concentration of HDL-cholesterol showed no significantly different in all treatment groups. Concentration of liver total cholesterol and triglyceride showed a tendence to decrease in Gal geun ext. groups. Concentration of plasma and liver TBARS showed a low values in Gal geun ext. groups. The values of GSH-Px and SOD activity showed no significantly different among all the treatment groups. However the values of SOD and CAT activity showed a high value in the Gal geun ext. groups.

Keywords

References

  1. Arner P, Pollare T, Lithell H, Livingston JN. 1987. Defective insulin receptor kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 30:437 https://doi.org/10.1007/BF00292549
  2. BidlackWR, Tappel AL. 1973.Damage tomicrosomalmembrane by lipid peroxidation. Lipids 8: 177-178 https://doi.org/10.1007/BF02544631
  3. Buege JA, Aust SD. 1978. Microsomal lipid peroxidation. In: Fleischer S, Packer Leds Methods in enzymelogy (London, Academic press) 52: 302-309
  4. Fan L, Zeng L, Zeng GY, Zhou YP, Zhang LY, Cheng Y. 1982. Pharmacological studies on radix purariae, Chin. Med. J., 95:145
  5. Flohe L, Becker R, Brigelius R, Lengfelder E, Otting F. 1992. Convenient assays for superoxide dismutase. CRC Handbook of free radicals and antioxidants in Biomedicine pp. 287-293
  6. Guerra MC, Speroni E, Broccoli M, Cangini M, Pasini P, Minghett A, Crespi-Perellino N, Mirasoli M, Cantelli G, Paolini M. 2000. Comparisons between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYT-catalvzed drug metabolism. Life Sci 67(24): 2997-3006 https://doi.org/10.1016/S0024-3205(00)00885-7
  7. Huh J. 1984. Donguibokam, Mansandong Seoul, 3: 726
  8. Huh LH, Kim HC, Lee SJ. 1987. Studies on anti-inflammatory activity and its mechanism of daidzein. J pharmaceut Soc Kor 31(1): 154-163
  9. Ishikawa T, Suzukawa M. 1997. Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am J Clin Nutr. 66(2): 261-266 https://doi.org/10.1093/ajcn/66.2.261
  10. Johnson LH, Hakan Borg LA. 1988. A spectro phtometric method for determination of catalase activity in small tissue samples. Analytical Biochemistry pp. 331-336
  11. Kang YH, Ha TY, Moon KD. 1996. Effects of pine needle extracts on serum and liver lipid contents in rats fed high fat diet. J. Korean Soc. Food Nutr. 25: 367-373
  12. Keung WM, Vallee BL, Kudzu R. 1998. an ancient chinese source of modern antidipsotropic agents. Phytochemistry 47(4): 499-506 https://doi.org/10.1016/S0031-9422(97)00723-1
  13. Kissebah AH, Alfarsi S, Adams PW, Wynn V. 1976. Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridemia in man. Diabetologia. 12:563-571 https://doi.org/10.1007/BF01220632
  14. Kolterman OG, Insel J, Saekow M, Olefsky JM. 1980. Mechanism of insulin resistance in human obesity. J Clin Invest 65:1272-1284 https://doi.org/10.1172/JCI109790
  15. Langanier S, Yu BP. 1987. Anti-lipoperoxidation action of food restriction. Biochem. Biophys Res. Comm. 145: 1185- 1202 https://doi.org/10.1016/0006-291X(87)91562-2
  16. Lee CH, Han SH,Min SG. 1995. The effects of Puerariae radix catechins administration on liver function in carbon tetrachloride treat rats. J Korean Sci Nutr 24(5): 713-719
  17. Lee E, Choi MY, Oh HS. 2000. Effects of Powdered Siho (Bupleuri Radix) on serum and liver lipid composition and Antioxidative capacity in rat fed high oxidized fat. Korean J. Nutrition 33: 502-506
  18. Lee E. 2003. Effects of powdered pine needle (Pinus densiflora seib et Zucc.) on serum and Liver Lipid Composition and Antioxidative, J. Korean Soc. Food Sci. Nutr. 32(6): 926- 930 https://doi.org/10.3746/jkfn.2003.32.6.926
  19. Lee E, Shin CO. 2007. Effects of Galgeun (Pueraria radix) extracts on plasma and liver lipid composition, liver function and antioxidative capacity in rats fed high oxidized fat. Korean J. Plant Res. 20(5):475-480
  20. Lee JS, Kim ES, Kim SW. 1999. Effects of extract of Puerariae radix on lipid peroxidation in ethanol-administered rats. J Korean Soc Food Sci Nutr 28(4):901-906
  21. Levander OA, PDeLoach D, Morris C, Moser PB. 1983. Platelet glutathione peroxidase activity as an index of selenium status in rats. J. Nutr. 113: 55-63 https://doi.org/10.1093/jn/113.1.55
  22. Miura K, Takeda R, Nakamoto H, Saito H. 1971. The chemical and pharmacological stuy of puerariae radix , Oyouyakuri, 5:247
  23. Nakamoto H, Iwasaki Y, Kizu H. 1977. The study of aqueous extract of puerariae radix IV, Yakugaku Zasshi, 97:103 https://doi.org/10.1248/yakushi1947.97.1_103
  24. Nielsen S, Jensen MD. 1997. Obesity and cardivascular disease is body structure a factor. Curr. Opin. Lipidol. 8:200-204 https://doi.org/10.1097/00041433-199708000-00002
  25. Oh MJ, Lee KS, Son HY, Kim SY. 1990. Antioxidative components of pueraria root. J Kor Soc Food Sci Tech 22(7): 793-792
  26. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358 https://doi.org/10.1016/0003-2697(79)90738-3
  27. Park CH,Kim NY, Nam EJ, Kim SH, Lee JH, Lee E. 2007. Effects of Hagocho(Prunella vulgaris L.), Gamgook (Chrysanthemum indicum L.) and Galgeun (Pueraria Radix) on plasma lipid composition and histological consideration in hyperlipidemic rat. Korean J. Plant Res. 20:22-27
  28. Saito M. 1988. Interaction between lipid peroxide formation and nutritional status. J. JPN Soc. Nutr. Food Sci. 41: 343-349 https://doi.org/10.4327/jsnfs.41.343
  29. Shibata S, Harada M, Murakami T. 1959. Constituents of japanese and chinese crude drugs II: Anti-spasmodic action of the constituents of puerariae Root, Yakugaku Zasshi, 79:863 https://doi.org/10.1248/yakushi1947.79.7_863
  30. Takayama S, Kahn CR, Kubo K, Foley JE. 1988. Alterations in insulin receptor autophosphorylation in insulin resistance: correlation with altered sensitivity to glucose transport and antilipolysis to insulin. J Clin Endocrinol Metab 66:992-999 https://doi.org/10.1210/jcem-66-5-992
  31. Ueda H, Tanoue K. 2000. Growth-depressing and cholesterollowering effects of quillaja and tea saponins in chicks as influenced by diet composition. Anim. Sci. J. 71(4): 393-399
  32. Vergroeson AT. 1997. Physiological effects of dietary linoleic acid. Nutr. Rev. 35: 1-9