References
- Zimmet P, Alberti KG, Shaw GJ. Global and societal implications of the diabetes epidemic. Nature 414: 782-787 (2001) https://doi.org/10.1038/414782a
- Friedman JM. A war on obesity, not the obese. Science 299: 856-858 (2003) https://doi.org/10.1126/science.1079856
- Cavaghan MK, Ehrmann DA, Polonsky KS. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J. Clin. Invest. 106: 329-333 (2000) https://doi.org/10.1172/JCI10761
- Moller DE. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414: 821-827 (2001) https://doi.org/10.1038/414821a
- Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes: Scientific review. J. Am. Med. Assoc. 287: 360-372 (2002) https://doi.org/10.1001/jama.287.3.360
- Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51: 1851-1858 (2002) https://doi.org/10.2337/diabetes.51.6.1851
-
Nah SY, Park HJ, McCleskey EW. A trace component of ginseng that inhibits
$Ca^{2+}$ channels through a pertussis toxin-sensitive G protein. P. Natl. Acad. Sci. USA 92: 8739-8743 (1995) - Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem. Pharmacol. 58: 1685-1693 (1999) https://doi.org/10.1016/S0006-2952(99)00212-9
-
Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Studies on the mechanism of the hypoglycemic activity of
$ginsenoside-Rb_2$ in streptozotocin-diabetic rats. Chem. Pharm. Bull. 33: 869-872 (1985) https://doi.org/10.1248/cpb.33.869 - Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch. Pharm. Res. 24: 214-221 (2001) https://doi.org/10.1007/BF02978260
- Vuksan V, Sievenpiper JL. Herbal remedies in the management of diabetes: Lessons learned from the study of ginseng. Nutr. Metab. Cardiovas. 15: 149-160 (2005) https://doi.org/10.1016/j.numecd.2005.05.001
- Lai DM, Tu YK, Liu IM, Chen PF, Cheng JT. Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 72: 9-13 (2006) https://doi.org/10.1055/s-2005-916177
-
Shang W, Yang Y, Jiang B, Zhou L, Liu S, Chen M. Ginsenoside
$Rb_1$ promotes adipogenesis in 3T3-L1 cells by enhancing PPAR2 and C/EBP gene expression. Life Sci. 80: 618-625 (2007) https://doi.org/10.1016/j.lfs.2006.10.021 - Koide H, Oda T. Pathological occurrence of glucose 6-phosphatase in serum in liver diseases. Clin. Chim. Acta 4: 554-561 (1959) https://doi.org/10.1016/0009-8981(59)90165-2
- Hara H, Miwa I, Okuda J. Inhibition of rat glucokinase by alloxan and ninhydrin. Chem. Pharm. Bull. 34: 4731-4737 (1986) https://doi.org/10.1248/cpb.34.4731
- Gall JC, Brewer GJ, Dern RJ. Studies of glucose-6-phosphate dehydrogenase activity of individual erythrocytes: The methemoglobin-elution test for identification of females heterozygous for G6PD deficiency. Am. J. Hum. Genet. 17: 359-368 (1965)
- Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159 (1987)
- Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP. Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30: e15-e25 (2002) https://doi.org/10.1093/nar/30.4.e15
- Winer J, Jung CK, Shackel I, Williams PM. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal. Biochem. 270: 41-49 (1999) https://doi.org/10.1006/abio.1999.4085
- Mitsumoto Y, Klip A. Development regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells. J. Biol. Chem. 267: 4957-4962 (1992)
- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RL. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419 (1985) https://doi.org/10.1007/BF00280883
- Hu E, Liang P, Spieoelman BM. Adipo Q is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271: 10697-10703 (1996) https://doi.org/10.1074/jbc.271.18.10697
- Kappes A, Lottler G. Influences of ionomycin, dibutyryl-cyclo AMP and tuymour necrosis factor-alpha on imtracellular amount and secretion of apM1 in differentiating primary human preadipocytes. Horm. Metab. Res. 32: 548-554 (2000) https://doi.org/10.1055/s-2007-978684
- Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Bioph. Res. Co. 257: 79-83 (1999) https://doi.org/10.1006/bbrc.1999.0255
- Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7: 941-953 (2001) https://doi.org/10.1038/90984
- Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Uchida S, Yamashita S, Moda M, Kita S, Ueki K, Eto K, Akanuma Y, Froquel P, Foufelle F, Ferre P, Carling D, Kimura S, Naqai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8: 1288-1295 (2002) https://doi.org/10.1038/nm788
- Aguielera CM, Gil-Campos M, Canete R, Gil A. Alteration in plasma and tissue lipids associated with obesity and metabolic syndrome. Clin. Sci. 114: 183-193 (2008) https://doi.org/10.1042/CS20070115
- Davies GF, Khandelwal RL, Wu L, Juurlink BH, Roesler WJ. Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: A peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism. Biochem. Pharmacol. 62: 1071-1079 (2001) https://doi.org/10.1016/S0006-2952(01)00764-X
- Al-Hasani H, Tschop MH, Cushman SW. Two birds with one stone: Novel glucokinase activator stimulates glucose-induced pancreatic insulin secretion and augments hepatic glucose metabolism. Mol. Interv. 3: 367-370 (2000) https://doi.org/10.1124/mi.3.7.367
- Katsanos CS. Lipid-induced insulin resistance in the liver: Role of exercise. Sports Med. 34: 955-965 (2004) https://doi.org/10.2165/00007256-200434140-00002
- Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F. Activation of AMP-activated protein kinase in the liver: A new strategy for the management of metabolic hepatic disorders. J. Physiol. 574: 41-53 (2006) https://doi.org/10.1113/jphysiol.2006.108506
- Saha AK, Ruderman NB. Malonyl-CoA and AMP-activated protein kinase: An expanding partnership. Mol. Cell Biochem. 253: 65-70 (2003) https://doi.org/10.1023/A:1026053302036
- Winder WW, Holmes BF. Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated. J. Appl. Physiol. 89: 2430-2437 (2000) https://doi.org/10.1152/jappl.2000.89.6.2430
- Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais JF, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 6: 924-928 (2000) https://doi.org/10.1038/78693
- Yun SN, Ko SK, Lee KH, Chung SH. Vinegar-processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice. Arch. Pharm. Res. 30: 587-595 (2007) https://doi.org/10.1007/BF02977653
-
Park MW, Ha JH, Chung SH. 20(S)-Ginsenoside
$Rg_3$ enhances glucose-stimulated insulin secretion and activates AMPK. Biol. Pharm. Bull. 31: 748-751 (2008) https://doi.org/10.1248/bpb.31.748