Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Search for Plant Extracts with Protective Effects of Pancreatic Beta Cell against Oxidative Stress

산화적 스트레스에 대한 췌장 베타 세포 보호활성 식물추출물 탐색

  • Lee, Dong-Sung (College of Pharmacy, Wonkwang University) ;
  • Jeong, Gil-Saeng (Institute of Radiological Imaging Science, Wonkwang University) ;
  • An, Ren-Bo (College of Pharmacy, Yanbian University) ;
  • Li, Bin (College of Pharmacy, Wonkwang University) ;
  • Byun, Erisa (College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
  • 이동성 (원광대학교 약학대학) ;
  • 정길생 (원광대학교 익산방사선영상과학연구소) ;
  • 안인파 (연변대학교 약학대학) ;
  • 리빈 (원광대학교 약학대학) ;
  • 변에리사 (원광대학교 약학대학) ;
  • 김윤철 (원광대학교 약학대학)
  • Published : 2008.12.31
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Abstract

Diabetes mellitus is metabolic disorder characterized by hyperglycemia caused by insufficient insulin secretion or insulin receptor insensitivity to endogenous insulin. It is well-known that hyperglycemia is one of the main causes of oxidative stress in both type 1 and 2 diabetes. Oxidative stress is related by death of pancreatic ${\beta}$ cell and dysfunction of ${\beta}$ cell. Although ${\beta}$ cell death or dysfunction is induced by many substances or molecules, increased evidences that oxidative stress plays a crucial role in ${\beta}$ cell death or dysfunction. Considering the importance of oxidative stress in the pathogenesis of diabetes mellitus, we investigated the cytoprotective effects against hydrogen peroxide-induced oxidative stress in pancreatic ${\beta}$ cell line RIN-m5F cell. 110 Plant sources were collected in Mt. Baek-du, and extracted with methanol. These extracts had been screened the protective effects against hydrogen peroxide-induced oxidative damage in RIN-m5F cells at 50 and 200 ${\mu}g$/ml. Of these, ten methanolic extracts, aerial part of Erigenron cannadensis, aerial part of Lespedeza juncea, whole plant of Alopecurus aequalis, fruit of Lycium chinense, leaf of Morus alba, rhizome of Polygonatum odoratum, root of Ampelosis japonica, whole plant of Ranunculus japonicus, aerial part of Polygonum sieboldii, rhizome of Arisaema amurense var. violaceum showed significant protective effects against hydrogen peroxide-induced oxidative damage in pancreatic ${\beta}$ cell line RIN-m5F cell.

Keywords

References

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