Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Analysis of Studies on Ojeok-san for Establishment of Evidence Based Medicine

EBM 기반 구축을 위한 오적산 연구 논문 분석

  • Lee, Nam-Hun (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyung (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Lee, Ho-Young (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Jung, Da-Young (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Choi, Ji-Yoon (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Lee, Jun-Kyoung (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Shin, Hyun-Kyoo (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
  • 이남헌 (한국한의학연구원 한약제제연구부) ;
  • 하혜경 (한국한의학연구원 한약제제연구부) ;
  • 이호영 (한국한의학연구원 한약제제연구부) ;
  • 정다영 (한국한의학연구원 한약제제연구부) ;
  • 최지윤 (한국한의학연구원 한약제제연구부) ;
  • 이준경 (한국한의학연구원 한약제제연구부) ;
  • 신현규 (한국한의학연구원 한약제제연구부)
  • Published : 2008.12.30
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Abstract

Objective : The purpose of this report was to provide the information about activity and safety of Ojeok-san by analyzing domestic/international papers about Ojeok-san. Methods : Domestic/international papers related to Ojeok-san were reviewed and analyzed. These papers were then classified by year, experimental method and subject. Results : The following results were obtained in this study. 1. The studies of Ojeok-san started from 1984 and has continuously increased. The studies were mainly focused on experimental models rather than clinical studies. 2. By subject, papers related to safety were most common with 5 papers among 20 papers. Besides there were papers related to efficacy of analgesic, anti-hyperlipidemic, anti-blood stasis and treatment for uterine myoma. 3. The papers related to safety were mainly focused on the effect of Okeok-san on liver function, renal function or metal concentration of organs such as blood, brain, liver, kidney and bone. Ojeok-san proved to be safe, but more clinical studies regarding the safety are needed hereafter. 4. Papers related to analgesic, anti-pyretic, anti-phlogistic activities of Ojeok-san were in vivo studies, and other papers were about anti-hyperlipidemic activity, apoptosis inducing activity on uterine myeloma cell line and anti blood static activity on hydrocortisone acetate induced blood statis model. 5. Case reports were about anti-lipidemia, analgesic effect for mastalgia/back pain and anxiety disorder due to climacteric changes. Conclusion : Ojeok-san is being used in various ways with analgesic, anti-pyretic, anti-phlogistic, anti-hyperlipidemic, anti-tumor or anti-blood statis activity. However, mechanism study should be conducted at the molecular biology level and more clinical studies on the efficacy of Ojeok-san are needed.

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