Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Efficient Synthesis of Cylindol A and the Proposed Structure of Cylindol B: The Structure of Cylindol B Still in Question

  • Chang, Jay-Hyok (Chemical Development Division, LG Life Sciences, Ltd./R&D) ;
  • Nam, Do-Hyun (Ulsan Fine Chemical Industry Center) ;
  • Shin, Hyun-Ik (Chemical Development Division, LG Life Sciences, Ltd./R&D)
  • Published : 2008.05.20
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Abstract

Highly efficient syntheses of cylindol A (1) and the proposed structure of cylindol B (2) have been accomplished using common synthetic transformations from symmetrical starting materials 7 and 11, respectively. The latter synthesis revealed that the proposed structure of the natural cylindol B was assigned incorrectly. Isomers of 2 such as 15 and 16 were synthesized as a possible candidate of the natural cylindol B. However, their spectral data also did not match that of the natural cylindol B. Therefore, the structure of the natural cylindol B is yet to be resolved.

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References

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Cited by

  1. ChemInform Abstract: Efficient Synthesis of Cylindol A and the Proposed Structure of Cylindol B: The Structure of Cylindol B Still in Question. vol.39, pp.41, 2008, https://doi.org/10.1002/chin.200841212