Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Determination of Parathion Metabolite, p-Nitrophenol in Urine of Parathion Factory Workers

  • Han, Don-Hee (Department of Occupational Health and Safety Engineering, Inje University) ;
  • Jung, Dong-Gyun (Department of Environmental Science, Kongju National University) ;
  • Shin, Ho-Sang (Department of Environmental Education, Kongju National University)
  • Published : 2008.05.20
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Abstract

Parathion is an organophosphate pesticide being legally applied for the purpose of agriculture and is being manufactured in Korea. A gas chromatography/mass spectrometric method was developed for the determination of parathion urinary metabolite, p-nitrophenol. p-Nitrophenol was extracted from weak acidic urine, and then measured by gas chromatography-mass spectrometry (selected ion monitoring). The recovery of pnitrophenol in the overall procedure was 88.2%. The detection limit of the assay was 1.0 $\mu$ g/L based upon assayed urine of 2.0 mL. The method was applied to the determination of p-nitrophenol in urine of workers of a parathion industry. Spot urines of workers of a parathion industry were sampled at the end of shift and pnitrophenol was analyzed using above developed method. p-Nitrophenol could be detected in all of the urine samples at concentrations varying from 3.0 to 681 $\mu$ g/L.

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