대한소아치과학회지 (Journal of the korean academy of Pediatric Dentistry)

  • 제35권4호
  • /
  • Pages.607-618
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  • 2008
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  • 1226-8496(pISSN)
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  • 2288-3819(eISSN)
대한소아치과학회 (Korean Academy of Pediatric Dentistry)
권호 표지

재식전 건조시간에 따른 Emdogain$^{(R)}$ 의 적용이 치근흡수에 미치는 영향 : 조직학적, 3차원영상 분석

THE EFFECT OF EMDOGAIN. APPLICATION IN REPLANTED BEAGLE'S ANTERIOR TEETH : 3- DIMENSIONAL AND HISTOLOGIC ANALYSIS

  • 엄찬용 (경희대학교 치과대학 소아치과학교실) ;
  • 최영철 (경희대학교 치과대학 소아치과학교실) ;
  • 박재홍 (경희대학교 치과대학 소아치과학교실) ;
  • 최성철 (경희대학교 치과대학 소아치과학교실)
  • Eom, Chan-Yong (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University) ;
  • Choi, Yeung-Chul (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University) ;
  • Park,, Jae-Hong (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University) ;
  • Choi, Sung-Chul (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
  • 발행 : 2008.11.30
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초록

완전탈구된 치아의 구강외 건조시간에 따른 Emdogain$^{(R)}$의 적용이 재식치의 치주조직의 치유반응에 미치는 효과를 관찰하기 위하여 체중 10-13 kg의 비글 3마리의 상하악 12개의 전치를 발거하여 재식하였다. 구강외 건조시간은 15(I 군), 30(II 군) 및 60분(III 군)으로 분류한 후, 각 군은 Emdogain$^{(R)}$을 적용한 실험군과 적용하지 않은 대조군을 두었다. 건조시간에 따른 Emdogain$^{(R)}$의 적용이 치주조직치유에 미치는 효과를 비교, 평가하기 위하여 치과용 cone beam CT를 이용한 3차원적 영상과 조직학적 관찰을 통하여 다음과 같은 결론을 얻었다. 1. 대조군과 실험군 모두에서 건조 시간이 길어질수록 재식 후 염증성 흡수가 현저히 증가하였다(P<0.001). 2. Emdogain$^{(R)}$의 적용은 대조군에 비하여 염증 억제 효과가 있는 것으로 나타났으며, 특히 I 군과 III 군에서 Emdogain$^{(R)}$ 을 적용한 실험군에서 염증성 흡수의 감소가 나타났으나(P<0.01), II군에서는 차이가 없었다. 3. 치근의 흡수는 치근단 1/3 부위(절편 16, 15, 14순으로)에서 주로 발생하였으며(P<0.05, 0.001), 또한 치경부 1/3 부위(P<0.05)에서도 현저히 나타났다. 4. 치아의 장축에 직각인 절단면에서 관찰된 흡수는 주로 협설측 부위에 주로 발생하였다(P>0.01).

This study three-dimensionally and histologically assessed the effect of Emdogain$^{(R)}$ on periodontal healing in replanted teeth in three beagle dogs which were 1 to 2 years old, weighing from 10 to 13 ㎏. Twelve maxillary and mandibular incisors were intentionally extracted and replanted after 15(Group I), 30(Group II) and 60(Group III) minutes of air dry storage with and without the application of Emdogain$^{(R)}$. The following conclusions could be drawn from the present investigation. 1. Increased incidence of inflammatory healing response in periodontal tissue was proportional to air dry time in Both control and experimental group(P<0.001). 2. Treatment Group showed lower inflammatory root resorption, especially there were statically significant in Group I, III(P<0.001, Group II : P=0.093). 3. Inflammatory root resorption were mainly occurred in apical third(14, 15-16 section)(P<0.05, 0.001), and cervical third(1 section)(P<0.05). 4. In view of horizontal section of long tooth axis, Main root resorption area were 1, 4, 5 line area(bucco-lingual area)(p<0.01).

키워드

참고문헌

  1. Andreasen JO, Andreasen FM : Textbook and color atlas of traumatic injuries to the teeth. 3rd edn. Munksgaard Publishers, 1994.
  2. Andreasen JO, Borum MK, Jacobsen HL, et al. : Replantation of 400 avulsed permanent incisors. 4. Factors related to periodontal ligament healing. Endod Dent Traumatol, 11:76-89, 1995. https://doi.org/10.1111/j.1600-9657.1995.tb00464.x
  3. 김광철, 이긍호 : 완전 탈구된 치아의 보관방법에 따른 재식 후 치주인대 회복과 섬유아세포의 변화에 관한 연구. 대한소아치과학회지, 16:36-56, 1989.
  4. Trope M, Friedman S : Periodontal healing of replanted dog teeth stored in Viaspan, milk and Hank's balanced salt solution. Endod Dent Traumatol, 8:183-188, 1992. https://doi.org/10.1111/j.1600-9657.1992.tb00240.x
  5. Andreasen JO, Borum MK, Jacobsen HL, et al. : Replantation of 400 avulsed permanent incisors. 1. Diagnosis of healing complications. Endod Dent Traumatol, 11:51-58, 1995. https://doi.org/10.1111/j.1600-9657.1995.tb00461.x
  6. Andreasen JO, Borum MK, Jacobsen HL, et al. : Replantation of 400 avulsed permanent incisors. 2. Factors related to pulpal healing. Endod Dent Traumatol, 11:59-68, 1995. https://doi.org/10.1111/j.1600-9657.1995.tb00462.x
  7. Andersson L, Bodin I : 1. Avulsed human teeth replanted within 15 minutes - a long-term clinical follow- up study. Endod Dent Traumatol, 6:37-42, 1990. https://doi.org/10.1111/j.1600-9657.1990.tb00385.x
  8. Selvig KA, Bjorvatn K, Claffey N : Effect of stannous fluoride and tetracycline on repair after delayed replantation of root planed teeth in dogs. Acta Odontol Scand, 48:107-112, 1990. https://doi.org/10.3109/00016359009005865
  9. Khin MM, Sae-Lim V : The effect of topical minocycline minocycline on replacement resorption of replanted monkeys'teeth. Dent Traumatol, 19:96-102, 2003. https://doi.org/10.1034/j.1600-9657.2003.00155.x
  10. Keum KY, Kwon OT, Spangberg LS, et al. : Effect of dexamethasone on root resorption after delayed replantation of rat tooth. J Endod, 29:810-813, 2003. https://doi.org/10.1097/00004770-200312000-00006
  11. Sae-Lim V, Ong WY, Li Z, et al. : The effect of basic fibroblast growth factor on delayed-replanted monkey teeth. J Periodontol, 75:1570-1578, 2004. https://doi.org/10.1902/jop.2004.75.12.1570
  12. 최성철, 이긍호 : 탈구치의 alendronate 도포가 재식 후염증반응에 미치는 효과. 대한소아치과학회지, 34:192-203, 2007.
  13. Hammarstrom L, Heijl L, Gestrelius S : Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol, 24:669-77, 1997. https://doi.org/10.1111/j.1600-051X.1997.tb00248.x
  14. Heijl L, Heden G, Svardstrom G, et al. : Enamel matrix derivative ($Emdogain{\circledR}$ ) in the treatment of intrabony periodontal defects. J Clin Periodontol, 24:705-14, 1997. https://doi.org/10.1111/j.1600-051X.1997.tb00253.x
  15. Iqbal MK, Bamaas NS : Effect of enamel matrix derivative ($Emdogain{\circledR}$) upon periodontal healing after replantation of permanent incisors in Beagle dogs. Dent Traumatol, 17: 36-45, 2001. https://doi.org/10.1034/j.1600-9657.2001.170107.x
  16. Barrett EJ, Kenny DJ, Tenenbaum HC, et al. : Replantation of permanent incisors in children using $Emdogain{\circledR}$. Dent Traumatol, 21:269-275, 2005. https://doi.org/10.1111/j.1600-9657.2005.00316.x
  17. Poi WR, Carvalho RM, Panzarini SR, et al. : Influence of enamel matrix derivative($Emdogain{\circledR}$) and sodium fluoride on the healing process in delayed tooth replantation: histologic and histometric analysis in rats. Dent Traumatol, 23:35-41, 2007.
  18. Kurol J, Owman-Moll P : Hyalunuzation and root resorption during early orthodontic tooth movement in adolescents. Angle Orthod, 68:161-5, 1998.
  19. Chan EKM, Darendeliler MA, Jones AS, et al. : A Calibration Method Used for Volumetric Measurement of Orthodontically Induced Root Resorption Craters. Ann Biomed Eng, 32:880-8, 2004. https://doi.org/10.1023/B:ABME.0000030263.68615.82
  20. Chan EKM, Darendeliler MA : Exploring the third dimension in root resorption. Orthod Craniofacial Res, 7:64-70, 2004. https://doi.org/10.1111/j.1601-6343.2004.00280.x
  21. Lam K, Sae-Lim V : The effect of Emdogain gel on periodontal healing in replanted monkeys'teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 97:100-107, 2004. https://doi.org/10.1016/S1079-2104(03)00318-4
  22. Lindskog S, Blomlof L, Hammarstrom L : Mitosis and microorganisms in the periodontal membrane after storage in milk or saliva. Scand J Dent Res, 91: 465-472, 1983.
  23. Blomlop L, Andrersson L, Lindskog S, et al. : Periodontal healing of replanted monkey teeth prevented from drying. Acta Odontol Scand, 41:117-123, 1983. https://doi.org/10.3109/00016358309162311
  24. Soder P-0, Otteskog P, Andreasen JO, et al. : Effect of drying on viability of periodontal membrane. Scand J Dent Res, 85:167-168, 1977.
  25. 문상희, 김왕근, 이창섭 등 : 재식한 치아에서 수산화칼슘을 사용한 근관치료. 대한소아치과학회지, 26:96-102, 1999.
  26. Thong YL, Messer HH, Siar CH, et al. : Periodontal response to two intracanal medicaments in replanted monkey incisors. Dent Traumatol, 17: 254-259, 2001. https://doi.org/10.1034/j.1600-9657.2001.170603.x
  27. Lindskog S, Blomlof L, Hammarstrom L : Repair of periodontal tissues in vivo and in vitro. J Clin Periodontol, 10:188-205, 1983. https://doi.org/10.1111/j.1600-051X.1983.tb02207.x
  28. Hamamoto Y, Kawasaki N, Jarnbring F, et al. : Effects and distribution of the enamel matrix derivative $Emdogain{\circledR}$ in the periodontal tissues of rat molars transplanted to the abdominal wall. Dent Traumatol, 18:12-23, 2002. https://doi.org/10.1034/j.1600-9657.2002.180102.x
  29. Schjott M, Andreasen JO : $Emdogain{\circledR}$ does not prevent progressive root resorption after replantation of avulsed teeth: a clinical study. Dent Traumatol, 21:46-50, 2005. https://doi.org/10.1111/j.1600-9657.2004.00295.x
  30. Araujo M, Hayacibara R, Sonohara M, et al. : Effect of enamel matrix proteins($Emdogain{\circledR}$) on healing after re-implantation of" periodontally compromised" roots. An experimental study in the dog. J Clin Periodontol, 30:855-61, 2003. https://doi.org/10.1034/j.1600-051X.2003.00400.x