대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제28권3호
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- Pages.453-463
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- 2007
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- 1226-9174(pISSN)
한국인 기관지 천식 환자에서 허설변증과 Glutathione-S-Transferase 유전자의 다형성 연구
Association Study of Glutathione-S-Transferase M1/T1 Gene Polymorphism with Deficiency-Excess Differentiation-syndrome in Korean Bronchial Asthmatics
- 유승렬 (경희대학교 한의과대학 폐계내과학 교실) ;
- 정승연 (경희대학교 한의과대학 폐계내과학 교실) ;
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정주호
(경희대학교 의과대학 약리학교실) ;
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김진주
(경희대학교 약학대학 약리학교실) ;
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정승기
(경희대학교 한의과대학 폐계내과학 교실)
- Yu, Seung-Ryeol (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University) ;
- Jeong, Seung-Yeon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University) ;
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Jung, Ju-Ho
(Department of Pharmacology, College of Medicine, Kyung Hee University) ;
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Kim, Jin-Ju
(Department of Pharmacology, College of Pharmacy, Kyung Hee University) ;
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Jung, Sung-Ki
(Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University)
- 발행 : 2007.09.30
초록
Backgrounds : Glutathione-s-transferase (GST) is a kind of phase II metabolism enzyme and plays an important role in the detoxification of various toxic chemicals. It was reported that the genetic polymorphism of GSTM1 and GSTT1 genes may be responsible for asthma development and susceptibility to allergy. Traditional oriental medicine uses a unique diagnostic technique. differentiation-syndrome. to analyze signs and symptoms of patients synthetically. Through differentiation-syndrome. asthma patients can be divided into two groups: the deficiency syndrome group (DSG) and the excess syndrome group (ESG). Objectives : The purpose of this study was to investigate the possible association of GST gene polymorphism with clinical phenotype by differentiation-syndrome of bronchial asthma patients. Materials and Methods : One hundred and ten participants were evaluated by pulmonary function test. Patients with 53 DSG and 31 ESG by differentiation-syndrome were assessed for genetic analysis. GSTM1 and GSTT1 deletion polymorphism was performed by polymerase chain reaction (PCR). Results : GSTM1 gene deletion was detected in 43.4% of individuals in the DSG and in 38.71 % in the ESG. The distribution of GSTM1 polymorphism between DSG and ESG was not significantly different [