The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 2
- /
- Pages.163-168
- /
- 2007
- /
- 1229-1765(pISSN)
- /
- 2288-7199(eISSN)
Effects of oral administration and herbal acupuncture with Sayeoksanhap-Pyeongweisan-Gamibang(SPG) on gene exdpression in rats damaged by CCl4
사역산합평위산가미방(四逆散合平胃散加味方)의 경구 투여와 약침이 사염화탄소에 의한 간 손상 모델 백서의 유전자 변화에 미치는 영향
- Kim, Hyung-Woo (College of Korean medicine Dongshin University) ;
- Jeong, Byeong-Han (College of Oriental medicine Dongeui University) ;
-
Kim, Gye-Yeop
(College of Public Health and Welfare Dongshin University)
;
-
Kim, Young-Kyun
(College of Oriental medicine Dongeui University)
;
- Baek, Jin-Woong (College of Korean medicine Dongshin University) ;
-
Cho, Su-In
(College of Korean medicine Dongshin University)
- 김형우 (동신대학교 한의과대학) ;
- 정병한 (동의대학교 한의과대학) ;
-
김계엽
(동신대학교 보건복지대학)
;
-
김영균
(동의대학교 한의과대학)
;
- 백진웅 (동신대학교 한의과대학) ;
-
조수인
(동신대학교 한의과대학)
- Published : 2007.06.30
Abstract
Objectives : This study was designed to investigate effects of Sayeoksanhap-Pyeongweisan-Gambang (SPG) on gene expression in rats damaged by CCl4 Methods : We investigated the effects of SPG on gene expression in terms of microarray methods in rat liver which were obtained from rats damaged by CCl4. Results : Decreased gene expressions, which were induced by single injection of CCl4, were restored to those in normal rats by administration of SPG or herbal acupuncture. In acupuncture group, gene expressions were restored by 80% of those in control group. In oral administration group and combination group, gene expressions were restored above 90% of those in cuntrol group. Conclusion : These results suggest that oral administraion of SPG was useful to protect liver against CCl4 by its restoration of gene expressions in liver resected from rat damaged by CCl4.