The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 2
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- Pages.13-16
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Acute Toxicity Study on Palmul-tang(Bawu-tang) in Mice
ICR마우스를 이용하여 팔물탕(八物湯)의 급성독성에 관한 연구
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Ma, Jin-Yeul
(Korea Institue of Oriental Medicine)
;
- Huang, Dae-Sun (Korea Institue of Oriental Medicine) ;
- Yu, Young-Beob (Korea Institue of Oriental Medicine) ;
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Ha, Hye-Kyung
(Korea Institue of Oriental Medicine)
;
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Shin, Hyun-Kyoo
(Korea Institue of Oriental Medicine)
- Published : 2007.06.30
Abstract
Objectives : Palmul-tang(Bawu-tang) has been traditionally prescribed a medicine as a restorative. Methods : In this study, we investigated the acute toxicity about water-extracted PalMul-tang(Bawu-tang). Twenty-five mice completed 14 days of oral Palmul-tang(Bawu-tang) at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg. Results : We observed survival rates, general toxicity, change of body weight, and autopsy. Conclusions : To be confirmed the data for the toxicity and safety problems of oriental medicine prescription. Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg). In conclusion, LD50 of Palmul-tang(Bawu-tang) was over 5000mg/kg and it is very safe to ICR mice.