• 대한본초학회지
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• 제22권2호
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• pp.13-16
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• 2007

Objectives : Palmul-tang(Bawu-tang) has been traditionally prescribed a medicine as a restorative. Methods : In this study, we investigated the acute toxicity about water-extracted PalMul-tang(Bawu-tang). Twenty-five mice completed 14 days of oral Palmul-tang(Bawu-tang) at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg. Results : We observed survival rates, general toxicity, change of body weight, and autopsy. Conclusions : To be confirmed the data for the toxicity and safety problems of oriental medicine prescription. Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg). In conclusion, LD50 of Palmul-tang(Bawu-tang) was over 5000mg/kg and it is very safe to ICR mice.

• 대한한의학회지
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• 제32권6호
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• pp.74-84
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• 2011

Objectives: Palmul-tang (hachimotsu-to in Japanese and bawu-tang in Chinese) is a mixture of eight herbs. It is traditionally used for the treatment of anemia, anorexia, general weakness, and female infertility in China, Japan, and Korea. In this study, we investigated the protective effects of Palmul-tang water extract (PTE) against ethanol-induced acute gastric injury in rats. Material and Methods: Acute gastric lesions were induced by intragastric administration of 5mL/kg body weight of absolute ethanol to each rat. Control group rats were given PBS orally and the ethanol group (EtOH group) received absolute ethanol (5mL/kg) by oral gavage. The positive control group and the PTE group were given oral doses of omeprazole (50mg/kg) or PTE (400mg/kg), respectively, 2 h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of PTE, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach. Results: PTE reduced ethanol-induced hemorrhage and hyperemia in the gastric mucosa. PTE reduced the increase in lipid peroxidation associated with ethanol-induced acute gastric lesions and increased mucosal GSH content and the activities of antioxidant enzymes. Conclusion: These results indicate that PTE protects gastric mucosa against ethanol-induced acute gastric injury by increasing antioxidant status. We suggest that PTE could be developed as an effective drug for the treatment of acute gastric injury.

• 한방안이비인후피부과학회지
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• 제34권1호
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• pp.112-135
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• 2021

2020년 7월부터 2020년 12월까지 일개 보건소 건강증진과에서 관할지역 거주 중증 장애인 중 뇌병변 장애와 지체 장애인을 대상으로 한의약 장애인 방문건강관리 표준프로그램을 진행하였고, 이 중 1명의 중증 지체 장애인이 구강 건조증을 앓고 있어, 한의 치료의 개입을 통한 통합적인 관리한 결과는 다음과 같다. 1. 팔물탕(八物湯) 연조엑스제를 포함한 한의 치료는 YDQ에 의해 음허(陰虛)로 변증된 지체 장애인의 약물 유발성 구강 건조를 완화시키고 삶의 질을 호전시켰다. 2. 건강 보험에 포함된 한의 치료를 제공하여 한·양방 통합적 개입으로 양약으로 발생한 구강 건조 증상을 관리할 수 있었다. 3. 6개월간 투약된 팔물탕(八物湯) 연조엑스로 인한 이상 반응은 없었다. 4. 팬데믹 상황에서 한의약 방문 진료와 전화 진료가 혼합된 형태의 공공보건기관의 한의약 건강증진사업으로 장애인의 SHCN를 충족하고 장애인의 만성 질환 관리가 가능한 부분을 확인할 수 있었다. 5. 본 연구는 한방안이비인후피부과 증상 및 질환도 보건소 한의약 건강증진사업으로 포함할 수 있는 가능성을 확인하였으며, 유관 학회의 협력 및 지원과 연구가 필요하다고 생각된다.