대한한의학회지 (The Journal of Korean Medicine)
- 제28권3호통권71호
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- Pages.165-172
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- 2007
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
5-HT 및 AEW로 소양증(搔痒症)을 유발한 흰쥐에 대한 갈근(葛根)의 진양(鎭痒)효과
Antipruritic Effects of Puerariae Radix on 5-HT or AEW-Induced Itch Behavior in Mice
- 한재복 (경희대학교 대학원 동서의학과, 경희대학교 한의과대학 본초학교실) ;
- 선보람 (경희대학교 대학원 동서의학과) ;
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부영민
(경희대학교 한의과대학 본초학교실) ;
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김호철
(경희대학교 한의과대학 본초학교실)
- Han, Jae-Bok (Department of East-West Medicine, Graduate School, Department of Herbal Pharmacology, College of Oriental Medicine) ;
- Sun, Bo-Ram (Department of East-West Medicine, Graduate School) ;
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Bu, Yung-Min
(Department of Herbal Pharmacology, College of Oriental Medicine) ;
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Kim, Ho-Cheol
(Department of Herbal Pharmacology, College of Oriental Medicine)
- 발행 : 2007.09.30
초록
Objectives : To find antipruritic herbal medicines, we screened the water extracts of four herbal medicines which have been frequently prescribed to treat dermatologic diseases in oriental medicine. Methods : Water extracts of Bupleuri Radix, Scutellariae Radix, Cimicifugae Rhizoma and Puerariae Radix were administered at a dose of 300 mg/kg to male ICR mice. 1 hour later, serotonin hydrochloride dissolved in physiologic saline at a concentration of 100 nmol / 50