Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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The anti-allergy and anti-inflammatory effect of Anemarrhenae Rhizoma in vivo and in vitro

  • Kim, Su-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University) ;
  • Jeong, Hyun-Ja (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University) ;
  • Myung, Noh-Yil (College of Pharmacy, Wonkwang University, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University) ;
  • Moon, Phil-Dong (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Ju-Young (Department of Herb Science, Shinsung College) ;
  • Yi, Byoung-Jae (College of Pharmacy, Wonkwang University) ;
  • Lee, Eun-Hyub (College of Pharmacy, Wonkwang University) ;
  • An, Nyeon-Hyung (College of Pharmacy, Wonkwang University) ;
  • Park, Seok-Jae (College of Pharmacy, Wonkwang University) ;
  • Kim, Min-Cheol (College of Pharmacy, Wonkwang University, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University) ;
  • Jun, Suk-Min (College of Pharmacy, Wonkwang University) ;
  • Lee, Ji-Hyun (College of Pharmacy, Wonkwang University) ;
  • Kim, Hyung-Min (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (College of Pharmacy, Wonkwang University) ;
  • Um, Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
  • Published : 2007.09.30
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Abstract

Anemarrhenae Rhizoma (AR) is used in traditional oriental medicine for various medicinal purposes. However, the exact mechanism that accounts for the anti-allergy and anti-inflammatory effects of the AR is still not fully understood. The aim of The present study is to elucidate whether and how AR modulates the allergic reactions in vivo, and inflammatory reaction in vitro. In this study, we showed that AR significantly decreased compound 48/80-induced systemic anaphylaxis, paw oedema, and histamine release from preparation of rat peritoneal mast cells. Also, AR inhibited the expression of inflammatory cytokine in PMA plus A23187-stimulated human mast cells (HMC-1). In addition, we showed that anti-inflammatory mechanism of AR is through suppression of nuclear factor-${\kappa}B$ activation $I{\kappa}B-{\alpha}$degradation. These results provided new insight into the pharmacological actions of AR as a potential molecule for therapy of inflammatory allergic diseases.

Keywords

References

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