대한한의학회지 (The Journal of Korean Medicine)

대한한의학회 (The Society of Korean Medicine)
권호 표지

Indomethacin으로 유발된 생쥐의 위와 회장 점막 염증에 미치는 지유탕(地楡湯)의 효과

The Effects of Jiyu-tang against Gastric and Ileac Mucosal Ulcer Induced by Indomethacin in Mouse

  • 강아미 (동국대학교 한의과대학 비계내과학 교실) ;
  • 최은영 (동국대학교 한의과대학 비계내과학 교실) ;
  • 김학재 (동국대학교 한의과대학 비계내과학 교실) ;
  • 한이수 (동국대학교 한의과대학 비계내과학 교실) ;
  • 임성우 (동국대학교 한의과대학 비계내과학 교실)
  • Kang, A-My (Dept. of Internal Medicine, College of Korean Medicine, Dongguk University) ;
  • Choi, En-Young (Dept. of Internal Medicine, College of Korean Medicine, Dongguk University) ;
  • Kim, Hak-Jae (Dept. of Internal Medicine, College of Korean Medicine, Dongguk University) ;
  • Han, Yi-Soo (Dept. of Internal Medicine, College of Korean Medicine, Dongguk University) ;
  • Lim, Seong-Woo (Dept. of Internal Medicine, College of Korean Medicine, Dongguk University)
  • 발행 : 2007.06.30
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초록

Objectives : This study was carried out to investigate the effect of Jiyu-tang on gastric and ileac mucosal ulcer induced by indomethacin in mouse. Methods : The normal group was that no inflammation elicited mouse. Control group is that water administered mouse after gastro-inflammation elicitation. Sample group is that Jiyu-tang administered mouse after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group were observed various injury by hemorrhagic erosion, while sample group was noticeably decreased than control group. In the immunohistochemical change, the distributions of COX-1 treated with Jiyu-tang noticeably increased than control group(p<0.05). The distributions of COX-2, MAC 387 and HSP-70, PCNA and TUNEL treated with Jiyu-tang noticeably decreased than control group(p<0.05). Conclusions : According to the above results, it is supposed that Jiyu-tang is applicable to gastric and ileac mucosal ulcer.

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