The Journal of Korean Medicine (대한한의학회지)
- Volume 28 Issue 2 Serial No. 70
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- Pages.200-204
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- 2007
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
Acute Toxicity Study on Sagunja-tang(Sijunzi-tang) in ICR Mice
ICR 마우스를 이용하여 사군자탕(四君子湯)의 급성 독성에 관한 연구
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Ma, Jin-Yeul
(Korea Institute of Oriental Medicine)
;
- Huang, Dae-Sun (Korea Institute of Oriental Medicine) ;
- Yu, Young-Beob (Korea Institute of Oriental Medicine) ;
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Ha, Hye-Kyung
(Korea Institute of Oriental Medicine)
;
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Shin, Hyun-Kyoo
(Korea Institute of Oriental Medicine)
- Published : 2007.06.30
Abstract
Objectives : The purpose of this study was to investigate acute toxicity of orally-treated Sagunja-tang(Sijunzi-tang) in ICR mice. Methods : In this study, we investigated the acute toxicity of water-extracted Sagunja-tang(Sijunzi-tang). Twenty-five mice completed 14 days of oral Sagunja-tang(Sijunzi-tang) at respective doses of 0 (control group), 2560, 3200, 4000 and 5000 mg/kg. Results : We observed survival rates, clinical signs of male ICR mice with acute toxicity, change of body weight and autopsy. Conclusions : Compared with the control group, we could not find any toxic alteration in anytreated groups (2560, 3200, 4000 and 5000mg/kg). LD50 of Sagunja-tang(Sijunzi-tang) was over 5000 mg/kg and it is very safe for ICR mice.