The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Dansam-san (丹蔘散) Inhibits Atherosclerosis through Regulation of Foam Cell Formation and Vascular Smooth Muscle Proliferation

단삼산(丹蔘散)의 거품세포 형성 및 혈관평활근세포 증식 억제를 통한 항동맥경화 효과

  • Ryu, Do-Kyun (Dept. of Oriental Medicine, Graduate School, Dongguk University) ;
  • Choi, Dong-Jun (Dept. of Oriental Medicine, Graduate School, Dongguk University) ;
  • Han, Chang-Ho (Dept. of Oriental Medicine, Graduate School, Dongguk University) ;
  • Jung, Seung-Hyun (Dept. of Oriental Medicine, Graduate School, Dongguk University) ;
  • Lee, Won-Chul (Dept. of Oriental Medicine, Graduate School, Dongguk University) ;
  • Kang, Yoon-Ho (Dept. of Oriental Medicine, Graduate School, Dongguk University) ;
  • Shin, Gil-Cho (Dept. of Oriental Medicine, Graduate School, Dongguk University)
  • 유도균 (동국대학교 한의과대학 내과학교실) ;
  • 최동준 (동국대학교 한의과대학 내과학교실) ;
  • 한창호 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 강윤호 (동국대학교 한의과대학 내과학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실)
  • Published : 2007.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : This study was carried out to investigate the inhibitive effect of a combined-herb prescription of Dansam-san (DSS) on formation of foam cells and cytokine. Methods : Experimental formation of foam cells was induced on macrophage RAW 264.7 with ox-LDL. The effect of DSS extract was observed by measuring the changes of CD36, $PPAR-{\Gamma}$, MMP-9, iNOS expression and changes of formation level of foam cells after treating experimentally induced foam cells with DSS extract. Then the antioxidative effect of DSS extract was compared with butylated hydroxyanisole (BHA). Result and Conclusions : Results obtained are as follows: 1. DSS extract showed significant antioxidative effect at 8 mg/ml or more. 2. DSS extract inhibited the formation of foam cells. 3. DSS extract inhibited the creation and revelation of conversion-related material about foam cells. 4. DSS extract prohibited the increase of smooth muscle of vessels.

Keywords