참고문헌
- Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K. and Yamamoto, M. (2001). Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol. Appl. Pharmacol., 173, 154-160 https://doi.org/10.1006/taap.2001.9176
- Chan, K., Han, X.D. and Kan, Y.W. (2001). An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. USA, 98, 4611-4616
- Chan, K. and Kan, Y.W. (1999). Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. USA, 96, 12731-12736
- Chen, C. and Kong, A.N. (2004). Dietary chemopreventive compounds and ARE/EpRE signaling. Free Radic. Biol. Med., 36, 1505-1516 https://doi.org/10.1016/j.freeradbiomed.2004.03.015
- Cho, H.Y., Jedlicka, A.E., Reddy, S.P., Kensler, T.W., Yamamoto, M., Zhang, L.Y. and Kleeberger, S.R. (2002a). Role of NRF2 in protection against hyperoxic lung injury in mice. Am. J. Respir. Cell Mol. Biol., 26, 175-182 https://doi.org/10.1165/ajrcmb.26.2.4501
- Cho, H.Y., Jedlicka, A.E., Reddy, S.P., Zhang, L.Y., Kensler, T.W. and Kleeberger, S.R. (2002b). Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. Am. J. Respir. Cell Mol. Biol., 26, 42-51 https://doi.org/10.1165/ajrcmb.26.1.4536
- Cho, H.Y., Reddy, S.P., Yamamoto, M. and Kleeberger, S.R.(2004). The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J., 18, 1258-1260 https://doi.org/10.1096/fj.03-1127fje
- Cho, M.K., Kim, W.D., Ki, S.H., Hwang, J.I., Choi, S., Lee, C.H. and Kim, S.G. (2007). Role of G{alpha}12 and G{alpha}13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor. Mol. Cell Biol., 27, 6195-6208 https://doi.org/10.1128/MCB.02065-06
- Dick, R.A., Kwak, M.K., Sutter, T.R. and Kensler, T.W. (2001). Antioxidative function and substrate specificity of NAD(P)Hdependent alkenal/one oxidoreductase. A new role for leukotriene B4 12- hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. J. Biol. Chem., 276, 40803-40810 https://doi.org/10.1074/jbc.M105487200
- Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T. and Yamamoto, M. (2001). High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of AREregulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci., 59, 169-177 https://doi.org/10.1093/toxsci/59.1.169
- Huang, H.C., Nguyen, T. and Pickett, C.B. (2002). Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J. Biol. Chem., 277, 42769-42774 https://doi.org/10.1074/jbc.M206911200
- Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S. and Yamamoto, M. (2000). Transcription factor Nrf2 coordinately regulates a group of oxidative stressinducible genes in macrophages. J. Biol. Chem., 275, 16023-16029 https://doi.org/10.1074/jbc.275.21.16023
- Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., Yamamoto, M. and Nabeshima, Y. (1997). An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun., 236, 313-322 https://doi.org/10.1006/bbrc.1997.6943
- Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K. and Yamamoto, M. (2004). Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Mol. Cell Biol., 24, 36-45 https://doi.org/10.1128/MCB.24.1.36-45.2004
- Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J.D. and Yamamoto, M. (1999). Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev., 13, 76-86 https://doi.org/10.1101/gad.13.1.76
- Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T. and Yamamoto, M. (2003). Keap1 regulates both cytoplasmic- nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells, 8, 379-391 https://doi.org/10.1046/j.1365-2443.2003.00640.x
- Kang, K.W., Cho, M.K., Lee, C.H. and Kim, S.G. (2001). Activation of phosphatidylinositol 3-kinase and Akt by tertbutylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells. Mol. Pharmacol., 59, 1147-1156 https://doi.org/10.1124/mol.59.5.1147
- Kang, K.W., Ryu, J.H. and Kim, S.G. (2000). The essential role of phosphatidylinositol 3-kinase and of p38 mitogenactivated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells. Mol. Pharmacol., 58, 1017-1025 https://doi.org/10.1124/mol.58.5.1017
- Kensler, T.W. (1997). Chemoprevention by inducers of carcinogen detoxication enzymes. Environ. Health Perspect, 105, 965-970 https://doi.org/10.2307/3433311
- Kobayashi, A., Kang, M.I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K. and Yamamoto, M. (2004). Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell Biol., 24, 7130-7139 https://doi.org/10.1128/MCB.24.16.7130-7139.2004
- Kwak, M.K., Cho, J.M., Huang, B., Shin, S. and Kensler, T.W. (2007). Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radic. Biol. Med., 43, 809-817 https://doi.org/10.1016/j.freeradbiomed.2007.05.029
- Kwak, M.K., Egner, P.A., Dolan, P.M., Ramos-Gomez, M., Groopman, J.D., Itoh, K., Yamamoto, M. and Kensler, T.W. (2001a). Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat. Res., 480-481, 305-315
- Kwak, M.K., Itoh, K., Yamamoto, M. and Kensler, T.W. (2002). Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell Biol., 22, 2883-2892 https://doi.org/10.1128/MCB.22.9.2883-2892.2002
- Kwak, M.K., Itoh, K., Yamamoto, M., Sutter, T.R. and Kensler, T.W. (2001b). Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole- 3-thione. Mol. Med., 7, 135-145
- Kwak, M.K., Ramos-Gomez, M., Wakabayashi, N. and Kensler, T.W. (2004). Chemoprevention by 1,2-dithiole-3-thiones through induction of NQO1 and other phase 2 enzymes. Methods Enzymol., 382, 414-423 https://doi.org/10.1016/S0076-6879(04)82022-6
- Kwak, M.K., Wakabayashi, N., Greenlaw, J.L., Yamamoto, M. and Kensler, T.W. (2003a). Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol. Cell Biol., 23, 8786-8794 https://doi.org/10.1128/MCB.23.23.8786-8794.2003
- Kwak, M.K., Wakabayashi, N., Itoh, K., Motohashi, H., Yamamoto, M. and Kensler, T.W. (2003b). Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem., 278, 8135- 8145 https://doi.org/10.1074/jbc.M211898200
- Lam, S., MacAulay, C., Le Riche, J.C., Dyachkova, Y., Coldman, A., Guillaud, M., Hawk, E., Christen, M.O. and Gazdar, A.F. (2002). A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia. J. Natl. Cancer. Inst., 94, 1001-1009 https://doi.org/10.1093/jnci/94.13.1001
- Lee, J.M., Calkins, M.J., Chan, K., Kan, Y.W. and Johnson, J.A. (2003). Identification of the NF-E2-related factor-2- dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J. Biol. Chem., 278, 12029-12038 https://doi.org/10.1074/jbc.M211558200
- Lee, J.M., Chan, K., Kan, Y.W. and Johnson, J.A. (2004). Targeted disruption of Nrf2 causes regenerative immunemediated hemolytic anemia. Proc. Natl. Acad. Sci. USA, 101, 9751-9756
- Lee, J.M., Hanson, J.M., Chu, W.A. and Johnson, J.A. (2001). Phosphatidylinositol 3-kinase, not extracellular signal- regulated kinase, regulates activation of the antioxidant- responsive element in IMR-32 human neuroblastoma cells. J. Biol. Chem., 276, 20011-20016 https://doi.org/10.1074/jbc.M100734200
- Li, J., Stein, T.D. and Johnson, J.A. (2004). Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol. Genomics, 18, 261-272 https://doi.org/10.1152/physiolgenomics.00209.2003
- McMahon, M., Itoh, K., Yamamoto, M., Chanas, S.A., Henderson, C.J., McLellan, L.I., Wolf, C.R., Cavin, C. and Hayes, J.D. (2001). The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res., 61, 3299-3307
- McMahon, M., Itoh, K., Yamamoto, M. and Hayes, J.D. (2003). Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem., 278, 21592-21600 https://doi.org/10.1074/jbc.M300931200
- Nguyen, T., Sherratt, P.J. and Pickett, C.B. (2003). Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol., 43, 233-260 https://doi.org/10.1146/annurev.pharmtox.43.100901.140229
- Otieno, M.A., Kensler, T.W. and Guyton, K.Z. (2000). Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo. Free Radic. Biol. Med., 28, 944-952 https://doi.org/10.1016/S0891-5849(00)00175-1
- Primiano, T., Gastel, J.A., Kensler, T.W. and Sutter, T.R. (1996). Isolation of cDNAs representing dithiolethione-responsive genes. Carcinogenesis, 17, 2297-2303 https://doi.org/10.1093/carcin/17.11.2297
- Primiano, T., Li, Y., Kensler, T.W., Trush, M.A. and Sutter, T.R. (1998). Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention. Carcinogenesis, 19, 999-1005 https://doi.org/10.1093/carcin/19.6.999
- Ramos-Gomez, M., Dolan, P.M., Itoh, K., Yamamoto, M. and Kensler, T.W. (2003). Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis, 24, 461-467 https://doi.org/10.1093/carcin/24.3.461
- Ramos-Gomez, M., Kwak, M.K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P. and Kensler, T.W. (2001). Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor- deficient mice. Proc. Natl. Acad. Sci. USA, 98, 3410- 3415
- Rangasamy, T., Cho, C.Y., Thimmulappa, R.K., Zhen, L., Srisuma, S.S., Kensler, T.W., Yamamoto, M., Petrache, I., Tuder, R.M. and Biswal, S. (2004). Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest., 114, 1248-1259 https://doi.org/10.1172/JCI200421146
- Suh, J.H., Shenvi, S.V., Dixon, B.M., Liu, H., Jaiswal, A.K., Liu, R.M. and Hagen, T.M. (2004). Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc. Natl. Acad. Sci. USA, 101, 3381-3386
- Talalay, P., De Long, M.J. and Prochaska, H.J. (1988). Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc. Natl. Acad. Sci. USA, 85, 8261-8265
- Thimmulappa, R.K., Mai, K.H., Srisuma, S., Kensler, T.W., Yamamoto, M. and Biswal, S. (2002). Identification of Nrf2- regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res., 62, 5196-5203
- Venugopal, R. and Jaiswal, A.K. (1996). Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc. Natl. Acad. Sci. USA, 93, 14960-14965
- Venugopal, R. and Jaiswal, A.K. (1998). Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene, 17, 3145-3156 https://doi.org/10.1038/sj.onc.1202237
- Wakabayashi, N., Dinkova-Kostova, A.T., Holtzclaw, W.D., Kang, M.L., Kobayashi, A., Yamamoto, M., Kensler, T.W. and Talalay, P. (2004). Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers. Proc. Natl. Acad. Sci. USA, 101, 2040-2045
- Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., Kotsuji, T., Otsuka, F., Roop, D.R., Harada, T., Engel, J.D. and Yamamoto, M. (2003). Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat. Genet., 35, 238- 245 https://doi.org/10.1038/ng1248
- Wang, J.S., Shen, X., He, X., Zhu, Y.R., Zhang, B.C., Wang, J.B., Qian, G.S., Kuang, S.Y., Zarba, A., Egner, P.A.,Jacobson, L.P., Munoz, A., Helzlsouer, K.J., Groopman, J.D. and Kensler, T.W. (1999). Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. J. Natl. Cancer Inst., 91, 347-354 https://doi.org/10.1093/jnci/91.4.347
- Wasserman, W.W. and Fahl, W.E. (1997). Functional antioxidant responsive elements. Proc. Natl. Acad. Sci. USA, 94, 5361-5366
- Wild, A.C., Moinova, H.R. and Mulcahy, R.T. (1999). Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J. Biol. Chem., 274, 33627-33636 https://doi.org/10.1074/jbc.274.47.33627
- Yoh, K., Itoh, K., Enomoto, A., Hirayama, A., Yamaguchi, N., Kobayashi, M., Morito, N., Koyama, A., Yamamoto, M. and Takahashi, S. (2001). Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int., 60, 1343- 1353 https://doi.org/10.1046/j.1523-1755.2001.00939.x
- Zhang, D.D. and Hannink, M. (2003). Distinct cysteine residues in keap1 are required for keap1-dependent ubiquitination of nrf2 and for stabilization of nrf2 by chemopreventive agents and oxidative stress. Mol. Cell Biol., 23, 8137- 8151 https://doi.org/10.1128/MCB.23.22.8137-8151.2003