Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
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Use of $^{18}F$-FDG PET/CT in Second Primary Cancer

이차성 원발암에서의 $^{18}F$-FDG PET/CT의 이용

  • Choi, Joon-Young (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Byung-Tae (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 최준영 (성균관대학교 의과대학 삼성서울병원 핵의학과) ;
  • 김병태 (성균관대학교 의과대학 삼성서울병원 핵의학과)
  • Published : 2007.06.30
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Abstract

This review focuses on the use of $^{18}F-FDG$ PET/CT to evaluate second primary cancers. The emergence of a second primary cancer is an important prognostic factor in cancer patients. The early detection of a second primary cancer and the appropriate treatment are essential for reducing the morbidity and mortality associated with these tumors. Integrated $^{18}F-FDG$ PET/CT, which can provide both the metabolic and anatomic information of a cancer, has been shown to have a better accuracy in oncology than either CT or conventional PET. The whole body coverage and high sensitivity of $^{18}F-FDG$ PET/CT along with its ability to provide both metabolic and anatomic information of a cancer make it suitable for evaluating a second primary cancer in oncology. Whole body $^{18}F-FDG$ PET/CT is useful for screening second primary cancers with a high sensitivity and good positive predictive value. In order to rule out the presence of a second primary cancer or an unexpected metastasis, further diagnostic work-up is essential when abnormal findings indicative of a second primary cancer are found on the PET/CT images. PET/CT is better in detecting a second primary tumor than conventional PET.

이 종설은 이차성 원발암에서의 $^{18}F-FDG$ PET/CT의 이용을 다루었다. 암환자에서 이차성 원발암의 발병 유무는 주요한 예후인자 중의 하나이다. 이차성 원발암을 조기에 진단하고 치료하는 것은 이와 관련된 암 사망률을 낮추는 데 중요하다. $^{18}F-FDG$ PET/CT는 해부학적 및 대사적 정보를 동시에 제공함으로써 종양 영역에서 CT나 기존의 PET보다 진단성능이 더 우수하다. 이러한 우수한 진단성능과 전신영상이 가능하다는 장점 때문에 PET/CT는 이차성 원발암을 발견하는 데에 CT나 기존의 PET보다 더 적합하다. $^{18}F-FDG$ PET/CT는 이차성 원발암에 대한 선별검사로서 높은 예민도와 비교적 좋은 양성예측도를 보이므로 유용하다. PET/CT 영상에서 이차성 원발암이 의심되는 병변이 보일 경우 추가적인 진단적 검사는 필수적이다. PET/CT는 이차성 원발암을 발견하는데 PET보다 우수하다.

Keywords

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