Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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The Effect of 5-Oxohexyl-3,7-dimethylxanthine on Carbon Tretrachlroride-Induced Hepatotoxicity in Rats

5-Oxohexyl-3,7-dimethylxanthine이 사염화탄소로 유발된 흰쥐의 간손상에 미치는 영향

  • Shin, Hea-Soon (College of Pharmacy, Duksung Women's University) ;
  • Lee, Bo-Ran (College of Pharmacy, Duksung Women's University)
  • 신혜순 (덕성여자대학교 약학대학) ;
  • 이보란 (덕성여자대학교 약학대학)
  • Published : 2007.09.30
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Abstract

A series of new derivatives of 1-(5-oxohexyl)-3,7-dimethylxanthine has been prepared for the treatment of the vascular dementia. To investigate hepatoprotective effect of these derivatives, the serum biochemical activity and the histological change of liver tissue were evaluated in carbon tetrachloride ($CCl_4$) treated rats. The activities of aspartate aminotransferase and alanine aminotransferase and the activities of total cholesterol, triglyceride and total bilirubin in 5-oxohexyl-3,7-dimethylxanthine derivatives pretreated rats were significantly decreased compared to the $CCl_4$ only treated rats but the content of glutathione S-transferase was increased compared to the $CCl_4$ only treated rats. These results indicated that 5-oxohexyl-3,7-dimethylxanthine derivatives have hepatoprotective effect in $CCl_4$ intoxicated rats.

Keywords

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