Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Clinical Characteristics of Acute Pure Organophosphate Compounds Poisoning - 38 Multi-centers Survey in South Korea -

국내 유기인계 농약 중독 환자의 특성 분석 - 다기관 연구 보고 분석 -

  • Lee, Mi-Jin (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kwon, Woon-Yong (Department of Emergency Medicine, Seoul National University College of medicine) ;
  • Park, Joon-Seok (Department of Emergency Medicine, College of Medicine, Konyang University) ;
  • Eo, Eun-Kyung (Department of Emergency Medicine, School of Medicine, Ewha Womans University) ;
  • Oh, Bum-Jin (Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sung-Woo (Department of Emergency Medicine, Korea University College of Medicine) ;
  • Suh, Joo-Hyun (Department of Internal Medicine, Gachon University of Medicine and Science) ;
  • Roh, Hyung-Keun (Department of Internal Medicine, Gachon University of Medicine and Science)
  • 이미진 (가톨릭대학교 의과대학 응급의학교실) ;
  • 권운용 (서울대학교 의과대학 응급의학교실) ;
  • 박준석 (건양대학교 의과대학 응급의학교실) ;
  • 어은경 (이화여자대학교 의학전문대학원 응급의학교실) ;
  • 오범진 (울산의대 서울아산병원 응급의학교실) ;
  • 이성우 (고려대학교 의과대학 응급의학교실) ;
  • 서주현 (가천의과학대학교 내과학교실) ;
  • 노형근 (가천의과학대학교 내과학교실)
  • Published : 2007.06.13
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Abstract

Purpose: Organophosphate (OP) compounds insecticides are the most commonly associated with serious human toxicity all over the world. The aim of this study was to identify sociocultural factors that contribute to high incidence of pure OP poisoning and prevent OP poisoning in order to reduce the factors responsible for deaths in South Korea. Methods: This is the 38 multi-centers survey and prospective study of pure OP poisoning by structural reporting system and hospital records from August 2005 to July 2006. 238 patients with acute pure OP poisoning were enrolled. We collected patient information regarding poisoning, clinical, and demographic features. Results: The mean age was $55.32{\pm}17.3$ years old. The most frequent site of exposure was their own residence(85.7%). Frequent compounds involving pure OP poisoning were dichlorvos(22.7%), methidathion(8.4%), and phosphamidon(6.7%). Intentional poisoning was 77.9%. The most frequently route of exposure was ingestion(94.5%). The mean arrival time to hospital after poisoning was 12.7 hours and mean hospitalization duration was 12.9 days. 2-PAM was administered to 101 patients in mean doses of 6.3 g/day intravenously. Atropine was administered to 81 patients in mean doses of 74.6 mg/day (maximal 910 mg/day). The presence of lower level of GCS score, respiratory complications, hypotension, acute renal failure, and serious dysrhythmia was associated with serious and fatal poisoning. Overall final mortality in pure OP poisoning was 9.7%(23/238). Conclusion: This study highlights the problem of pure OP poisoning in South Korea as a basic national survey. Futhermore this might help the establishment of strict policies availability of OP and the statistics of OP poison exposure in South Korea.

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