Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Synchronous Double Primary Cancers of Lung and Liver

폐와 간의 동시성 원발성 중복암

  • Lim, So Yeon (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Sim, Yun Su (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Lee, Jin Hwa (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Kim, Tae-Hun (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Ryu, Yon Ju (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Chun, Eun Mi (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Kim, Yoo Kyung (Department of Radiology, Ewha Womans University College of Medicine) ;
  • Lee, Jung Kyong (Department of Radiology, Ewha Womans University College of Medicine) ;
  • Sung, Sun Hee (Department of Pathology, Ewha Womans University College of Medicine) ;
  • Ahn, Jae Ho (Department of Thoracic Surgery, Ewha Womans University College of Medicine) ;
  • Chang, Jung Hyun (Department of Internal Medicine, Ewha Womans University College of Medicine)
  • 임소연 (이화여자대학교 의과대학 내과학교실) ;
  • 심윤수 (이화여자대학교 의과대학 내과학교실) ;
  • 이진화 (이화여자대학교 의과대학 내과학교실) ;
  • 김태헌 (이화여자대학교 의과대학 내과학교실) ;
  • 류연주 (이화여자대학교 의과대학 내과학교실) ;
  • 천은미 (이화여자대학교 의과대학 내과학교실) ;
  • 김유경 (이화여자대학교 의과대학 방사선과학교실) ;
  • 이정경 (이화여자대학교 의과대학 방사선과학교실) ;
  • 성순희 (이화여자대학교 의과대학 병리학교실) ;
  • 안재호 (이화여자대학교 의과대학 흉부외과학교실) ;
  • 장중현 (이화여자대학교 의과대학 내과학교실)
  • Received : 2007.01.23
  • Accepted : 2007.03.09
  • Published : 2007.04.30
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Abstract

Although reports of multiple primary malignant tumors have increased recently, cases of synchronous double primary tumors of lung and liver are rare. A 73-year-old man suffered from chronic cough. His chest x-ray showed segmental atelectasis of the right upper lobe. Bronchoscopy revealed a mass occluding the orifice of the anterior segmental bronchus of the right upper lobe, and a biopsy showed a squamous cell carcinoma. A synchronous hepatic mass was found by ultrasonography. However, F18-FDG-PET showed no evidence of a distant metastasis. The liver biopsy revealed a hepatocellular carcinoma. A right upper lobe lobectomy and a sleeve resection were performed for the lung cancer, and radiofrequency ablation was performed for the hepatocellular carcinoma.

최근 평균수명의 연장과 진단 및 치료 방법의 발달로 원발성 중복암의 발견율이 높아지고 있다. 폐와 간에 발생한 중복암, 특히 동시성 중복암에 대한 보고는 매우 드물다. 저자 등은 만성기침을 호소하는 73세 남자에서 폐의 편평상피세포암을 진단한 후, 복부초음파에서 간 종괴를 발견하여 폐암의 전이를 의심하였으나 FDG-PET에 간 전이가 없어서 초음파 유도로 간 생검을 시행한 결과 간세포암을 진단하여, 폐와 간의 동시성 중복암을 경험하였기에 문헌고찰과 더불어 보고한다.

Keywords

References

  1. Engin K. Cancers in multiple primary sites. Int Surg 1994;79:33-7
  2. Cheng HY, Chu CH, Chang WH, Hsu TC, Lin SC, Liu CC, et al. Clinical analysis of multiple primary malignancies in the digestive system: a hospital-based study. World J Gastroenterol 2005;11:4215-9 https://doi.org/10.3748/wjg.v11.i27.4215
  3. Warren S, Gates O. Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer 1932;16:1358-414
  4. Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. II. Tumors of different tissues or organs. Cancer 1961;14:231-7 https://doi.org/10.1002/1097-0142(196103/04)14:2<231::AID-CNCR2820140203>3.0.CO;2-2
  5. Cleary JB, Kazarian KK, Mersheimer WL. Multiple primary cancer. Thirty patients with three or more primary cancers. Am J Surg 1975;129:686-90 https://doi.org/10.1016/0002-9610(75)90346-3
  6. Yoon HK, Kim JP. Multiple primary malignant neoplasm. J Korean Surg Soc 1984;26:1-9
  7. Koo DJ, Yoon DS, Lee JJ, Park CJ. Clinical analysis of 65 multiple primary cancer cases. J Korean Surg Soc 1999;56:137-42
  8. Bordin GM, Key CR, McQuade CE, Kutvirt DM, Hughes WB, Brylinski DA. Multiple primary cancers: relative risk in New Mexico's triethnic population. Cancer 1977;40:1793-800 https://doi.org/10.1002/1097-0142(197710)40:4+<1793::AID-CNCR2820400804>3.0.CO;2-7
  9. Huh WY, Kim HS, Lee SH, Kim EH, Kim MC, Kim KW, et al. Multiple primary cancers associated with lung cancer. J Korean Cancer Assoc 1994;26:425-30
  10. Riesz T, Jako JM, Juhasz J. Secondary malignant tumors accompanied by primary hepatocellular carcinoma. Acta Hepatogastroenterol 1979;26:364-7
  11. Lin DY, Liaw YF, Wu CS, Chang-Chien CS, Chen PC, Chen TJ. Hepatocellular carcinoma associated with second primary malignancy. Liver 1987;7:106-9
  12. Onitsuka A, Hirose H, Ozeki Y, Hino A, Senga S, Iida T. Clinical study on hepatocellular carcinoma with extrahepatic malignancies. Int Surg 1995;80:128-30
  13. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 1981;2:1129-33
  14. Trichopoulos D, Tabor E, Gerety RJ, Xirouchaki E, Sparros L, Munoz N, et al. Hepatitis B and primary hepatocellular carcinoma in a European population. Lancet 1978;2:1217-9
  15. Choi D, Kim H, Lee KG, Park HK, Kwon OJ, Lee KS. Clinicopathologic characteristics of hepatocellular carcinoma with extrahepatic malignancy. J Korean Surg Soc 2003;64:487-92