폐와 간의 동시성 원발성 중복암

Synchronous Double Primary Cancers of Lung and Liver

  • 임소연 (이화여자대학교 의과대학 내과학교실) ;
  • 심윤수 (이화여자대학교 의과대학 내과학교실) ;
  • 이진화 (이화여자대학교 의과대학 내과학교실) ;
  • 김태헌 (이화여자대학교 의과대학 내과학교실) ;
  • 류연주 (이화여자대학교 의과대학 내과학교실) ;
  • 천은미 (이화여자대학교 의과대학 내과학교실) ;
  • 김유경 (이화여자대학교 의과대학 방사선과학교실) ;
  • 이정경 (이화여자대학교 의과대학 방사선과학교실) ;
  • 성순희 (이화여자대학교 의과대학 병리학교실) ;
  • 안재호 (이화여자대학교 의과대학 흉부외과학교실) ;
  • 장중현 (이화여자대학교 의과대학 내과학교실)
  • Lim, So Yeon (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Sim, Yun Su (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Lee, Jin Hwa (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Kim, Tae-Hun (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Ryu, Yon Ju (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Chun, Eun Mi (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Kim, Yoo Kyung (Department of Radiology, Ewha Womans University College of Medicine) ;
  • Lee, Jung Kyong (Department of Radiology, Ewha Womans University College of Medicine) ;
  • Sung, Sun Hee (Department of Pathology, Ewha Womans University College of Medicine) ;
  • Ahn, Jae Ho (Department of Thoracic Surgery, Ewha Womans University College of Medicine) ;
  • Chang, Jung Hyun (Department of Internal Medicine, Ewha Womans University College of Medicine)
  • 투고 : 2007.01.23
  • 심사 : 2007.03.09
  • 발행 : 2007.04.30

초록

최근 평균수명의 연장과 진단 및 치료 방법의 발달로 원발성 중복암의 발견율이 높아지고 있다. 폐와 간에 발생한 중복암, 특히 동시성 중복암에 대한 보고는 매우 드물다. 저자 등은 만성기침을 호소하는 73세 남자에서 폐의 편평상피세포암을 진단한 후, 복부초음파에서 간 종괴를 발견하여 폐암의 전이를 의심하였으나 FDG-PET에 간 전이가 없어서 초음파 유도로 간 생검을 시행한 결과 간세포암을 진단하여, 폐와 간의 동시성 중복암을 경험하였기에 문헌고찰과 더불어 보고한다.

Although reports of multiple primary malignant tumors have increased recently, cases of synchronous double primary tumors of lung and liver are rare. A 73-year-old man suffered from chronic cough. His chest x-ray showed segmental atelectasis of the right upper lobe. Bronchoscopy revealed a mass occluding the orifice of the anterior segmental bronchus of the right upper lobe, and a biopsy showed a squamous cell carcinoma. A synchronous hepatic mass was found by ultrasonography. However, F18-FDG-PET showed no evidence of a distant metastasis. The liver biopsy revealed a hepatocellular carcinoma. A right upper lobe lobectomy and a sleeve resection were performed for the lung cancer, and radiofrequency ablation was performed for the hepatocellular carcinoma.

키워드

참고문헌

  1. Engin K. Cancers in multiple primary sites. Int Surg 1994;79:33-7
  2. Cheng HY, Chu CH, Chang WH, Hsu TC, Lin SC, Liu CC, et al. Clinical analysis of multiple primary malignancies in the digestive system: a hospital-based study. World J Gastroenterol 2005;11:4215-9 https://doi.org/10.3748/wjg.v11.i27.4215
  3. Warren S, Gates O. Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer 1932;16:1358-414
  4. Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. II. Tumors of different tissues or organs. Cancer 1961;14:231-7 https://doi.org/10.1002/1097-0142(196103/04)14:2<231::AID-CNCR2820140203>3.0.CO;2-2
  5. Cleary JB, Kazarian KK, Mersheimer WL. Multiple primary cancer. Thirty patients with three or more primary cancers. Am J Surg 1975;129:686-90 https://doi.org/10.1016/0002-9610(75)90346-3
  6. Yoon HK, Kim JP. Multiple primary malignant neoplasm. J Korean Surg Soc 1984;26:1-9
  7. Koo DJ, Yoon DS, Lee JJ, Park CJ. Clinical analysis of 65 multiple primary cancer cases. J Korean Surg Soc 1999;56:137-42
  8. Bordin GM, Key CR, McQuade CE, Kutvirt DM, Hughes WB, Brylinski DA. Multiple primary cancers: relative risk in New Mexico's triethnic population. Cancer 1977;40:1793-800 https://doi.org/10.1002/1097-0142(197710)40:4+<1793::AID-CNCR2820400804>3.0.CO;2-7
  9. Huh WY, Kim HS, Lee SH, Kim EH, Kim MC, Kim KW, et al. Multiple primary cancers associated with lung cancer. J Korean Cancer Assoc 1994;26:425-30
  10. Riesz T, Jako JM, Juhasz J. Secondary malignant tumors accompanied by primary hepatocellular carcinoma. Acta Hepatogastroenterol 1979;26:364-7
  11. Lin DY, Liaw YF, Wu CS, Chang-Chien CS, Chen PC, Chen TJ. Hepatocellular carcinoma associated with second primary malignancy. Liver 1987;7:106-9
  12. Onitsuka A, Hirose H, Ozeki Y, Hino A, Senga S, Iida T. Clinical study on hepatocellular carcinoma with extrahepatic malignancies. Int Surg 1995;80:128-30
  13. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 1981;2:1129-33
  14. Trichopoulos D, Tabor E, Gerety RJ, Xirouchaki E, Sparros L, Munoz N, et al. Hepatitis B and primary hepatocellular carcinoma in a European population. Lancet 1978;2:1217-9
  15. Choi D, Kim H, Lee KG, Park HK, Kwon OJ, Lee KS. Clinicopathologic characteristics of hepatocellular carcinoma with extrahepatic malignancy. J Korean Surg Soc 2003;64:487-92