Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Metabolic Regulation of Homocysteine in Type 2 Diabetic Goto-Kakizaki Rats

당뇨병 Goto-Kakizaki 랫트에서 호모시스테인의 대사조절

  • Oh, Jung-Min (College of Pharmacy and Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Yeo, Su-Jeong (College of Pharmacy and Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Kim, Bong-Hee (College of Pharmacy and Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Kim, Sang-Kyum (College of Pharmacy and Research Center for Transgenic Cloned Pigs, Chungnam National University)
  • 오정민 (충남대학교 약학대학 형질전환 복제돼지 센터) ;
  • 여수정 (충남대학교 약학대학 형질전환 복제돼지 센터) ;
  • 김봉희 (충남대학교 약학대학 형질전환 복제돼지 센터) ;
  • 김상겸 (충남대학교 약학대학 형질전환 복제돼지 센터)
  • Published : 2007.06.30
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Abstract

Elevation of homocysteine levels is a risk factor for cardiovascular diseases and liver diseases. It has been reported that both streptozotocin-induced type I diabetic rats and obese type II diabetic rats have plasma total homocysteine lower than each control rats. We determined the effects of lean type II diabetes on homocysteine levels using type 2 diabetic Goto-Kakizaki rats. The concentrations of serum glucose were increased to ${\sim}two-fold$ of control levels and the total cholesterol levels were also increased in GK rats. Hepatic aspartate, histidine, threonine, alanine and methionine levels were significantly increased in GK rats. Plasma aspartate and glutamate levels were elevated, but threonine and arginine levels were decreased in GK rats. Plasma total homocysteine levels were not changed in GK rats, but hepatic total homocysteine levels were increased to ${\sim}three-fold$ of control levels. These results suggest that hepatic metabolism of sulfur-amino acid may be altered in diabetic condition.

Keywords

References

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