Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
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Skin Irritation and Sensitization Studies on a Disinfectant Composed of 4-Chloro-m-cresol, Didecyl Dimethyl Ammonium Chloride, and Glutaraldehyde for the Bactericide

4-Chloro-m-cresol, Didecyl Dimethyl Ammonium Chloride 그리고 Glutaraldehyde로 구성된 살균 소독제에 대한 피부 자극성 및 감작성 시험에 관한 연구

  • Chung, Hee-Sik (Hapcheon Country Office) ;
  • Kim, Suk (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Chung, Myung-Sun (College of Veterinary Medicine, Seoul National University) ;
  • Jung, Won-Chul (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Dong-Hyeok (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lim, Jeong-Ju (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Shon, Ho-Yeong (Agricultural Technology Center, Yangsan City Hall) ;
  • Kim, Moo-Suk (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Gon-Sup (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hu-Jang (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 정희식 (경상남도 합천 군청) ;
  • 김석 (경상대학교 수의과대학 동물의학연구소) ;
  • 천명선 (서울대학교 수의학과) ;
  • 정원철 (경상대학교 수의과대학 동물의학연구소) ;
  • 김동혁 (경상대학교 수의과대학 동물의학연구소) ;
  • 임정주 (경상대학교 수의과대학 동물의학연구소) ;
  • 손호영 (경상남도 양산시 농업기술센터) ;
  • 김무석 (경상대학교 수의과대학 동물의학연구소) ;
  • 김곤섭 (경상대학교 수의과대학 동물의학연구소) ;
  • 이후장 (경상대학교 수의과대학 동물의학연구소)
  • Published : 2007.06.30
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Abstract

This test was performed to evaluate the skin irritation and sensitization of Creocomplex, disinfectant, Containing 10% 4-chloro-m-cresol, 10% didecyl dimethyl ammonium chloride, and 10% glutaraldehyde. In primary skin irritation test, rabbits were dermally treated with Creocomplex for 24 hrs. The disinfectant did not induce any adverse reactions such as erythema and edema on intact skin sites, but on abraded skin sites, some rabbits showed very slight erythema and edema 24hr after topical application. So, the disinfectant was classified as a practically non-irrifating material based on the score 0.13 of primary irritation index. In the skin sensitization test, guinea pigs were sensitized with intradermal injection of 0.1ml Creocomplex for 24 hr. After 1 week, Creocomplex was treated on the site of injection, and challenged 2 weeks later. Creocomplex did not induce any allergic reactions. Therefore, 10% Creocomplex was graded as a weak material from 0 in both sensitization score· and rate. From results of the present study, it is suggested that 10% Creocomplex does not cause contact irritation and sensitization.

살균소독제, 크레오콤플렉스 (4-chloro-m-cresol(10%), didecyldimethyl ammonium chloride(10%), glutaraldehyde (10%))에 대하여 토끼와 기니픽을 이용하여 피부 자극성 및 감작성 평가를 각각 수행하였다. 토끼의 등 부위의 털을 제거하고 찰과부위와 비찰과 부위에 여러 농도로 크레오콤플렉스를 도포한 후, 피부 자극성을 확인한 결과 10% 크레오콤플렉스의 1차 자극지수가 0.13으로 비자극성 물질로 분류되었다. 기니픽을 이용한 피부 감작성 시험에서는 1, 2차 감작 후, 2주 후 10% 크레오콤플렉스로 감작을 유도한 결과, 어떠한 알러지 반응도 보이지 않아, 감작성이 매우 약한 물질로 분류되었다. 따라서, 본 연구를 통하여, 10% 크레오콤플렉스는 피부자극성과 감작성을 야기하지 않는 물질로 평가되었다.

Keywords

References

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