Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Effect of Domestic Rose Flower Extracts on the Growth of Chinese Hamster Ovary Cells

국내산 장미꽃 추출물이 Chinese Hamster Ovary 세포 증식에 미치는 영향

  • Chun, Hye-Kyung (Division of Agriproduct Processing, Rural Resources Development Institute, National Institute of Agricultural Science and Technology) ;
  • Park, Hong-Ju (Division of Agriproduct Processing, Rural Resources Development Institute, National Institute of Agricultural Science and Technology) ;
  • Yoo, Byung-Sun (Division of Natural Science, Gyonggi University) ;
  • Cho, Yong-Sik (Division of Agriproduct Processing, Rural Resources Development Institute, National Institute of Agricultural Science and Technology)
  • 전혜경 (농업과학기술원 농촌자원개발연구소 농산물가공이용과) ;
  • 박홍주 (농업과학기술원 농촌자원개발연구소 농산물가공이용과) ;
  • 유병선 (경기대학교 자연과학부) ;
  • 조용식 (농업과학기술원 농촌자원개발연구소 농산물가공이용과)
  • Published : 2007.06.30
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Abstract

The effects of rose flower extracts on the growth of CHO cells were examined. Rose flower extracts were prepared by solvent extraction with hexane, ethylacetate and ether from five domestic rose cultivar, Rosa hybrida L. cv. Mihyang, Noeul, Redqueen, Whitelady and Pinklady, respectively. The effects of rose flower extracts on the growth of CHO cells were measured using MTT colormeteric assay and compared with control. Extracts of rose flowers showed stimulative effect or inhibitory effect on the growth of CHO cells depending on the kinds of solvent and concentration of extracts. Ether extracts of rose flower showed a more effective stimulative effect on the growth of CHO cells at the concentration of 5 ${\mu}g{\cdot}ml^{-1}$. These results suggest that rose flower has the simulating activity on the growth of CHO cells and a potential as new functional food source.

국내에서 새로 육성된 장미의 부가가치를 향상시키고 천연 식품소재로서 기능성을 탐색하는 기초연구의 일환으로 5개 장미 품종을 대상으로 유기용매 추출물을 제조하고 장미꽃 추출물이 CHO 세포의 생육에 미치는 영향을 MTT법으로 조사하였다. 장미 추출물들은 추출용매의 종류와 첨가농도에 따라 CHO 세포의 증식을 촉진하거나 생육을 억제하였으며 품종에 따른 차이는 없었다. Ether로 추출한 장미꽃 추출물을 5 ${\mu}$g/ml 농도로 첨가한 경우 대조군에 비하여 CHO 세포의 증식촉진효과가 가장 높았다. 이러한 결과는 장미꽃은 CHO 세포의 증식을 조절하는 생리활성을 나타내며, 신 기능성 식품소재로서 활용하는 가능성을 시사한다.

Keywords

References

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