한국식생활문화학회지 (Journal of the Korean Society of Food Culture)

  • 제22권1호
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  • Pages.157-165
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  • 2007
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  • 1225-7060(pISSN)
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  • 2288-7148(eISSN)
한국식생활문화학회 (Korean Society of Food Culture)
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탄수화물의 급원과 식이섬유의 종류를 달리한 식이가 제 2형 당뇨 쥐의 당대사 및 지질대사에 미치는 영향

Effect of Feeding with Different Source of Carbohydrate and Fiber on Carbohydrate and Lipid Metabolism in Type 2 Diabetic Rats

  • 권상희 (이화여자대학교 식품영양학과) ;
  • 정혜진 (이화여자대학교 식품영양학과) ;
  • 심지애 (이화여자대학교 식품영양학과) ;
  • 손영애 (이화여자대학교 식품영양학과) ;
  • 김미경 (이화여자대학교 식품영양학과)
  • Kwon, Sang-Hee (Department of Food & Nutrition Sciences, Ewha Womans University) ;
  • Jeong, Hye-Jin (Department of Food & Nutrition Sciences, Ewha Womans University) ;
  • Shim, Jee-Ae (Department of Food & Nutrition Sciences, Ewha Womans University) ;
  • Son, Young-Ae (Department of Food & Nutrition Sciences, Ewha Womans University) ;
  • Kim, Mi-Kyung (Department of Food & Nutrition Sciences, Ewha Womans University)
  • 발행 : 2007.02.28
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초록

This study was designed to evaluate the effects of fructose(F) or sucrose(S) and guar gum intake on carbohydrate and lipid metabolism in 15-week-old male Goto-Kakizaki(GK) rats. Fifty rats were randomly assigned to 5 groups which were different in carbohydrate(25% of carbohydrate) and fiber(5% w/w) sources. The carbohydrate(CHO) sources of each group were comstarch(control group, 100% of CHO), fructose with cellulose(F), fructose with guar gum(FG), sucrose with cellulose(S), and sucrose with guar gum(SG). Each group was fed exterimental diet for 4 weeks. We measured food intake, body weight gain, adipose tissues weight and organs weight. We conducted oral glucose tolerance test(OGTT) and measured plasma insulin concentration to examine carbohydrate metabolism. To evaluate lipid metabolism, we measured the lipid profile of plasma, liver and feces. Food intake and weight gain of FG or SG groups tended to be less than those of F or S groups. Perirenal and epididymal fat pad weights of SG group were significantly lower than those of S group and those of FG group tended to be lower than those of F group. In OGTT, blood glucose values of F or S groups were significantly higher than those of C group, and FG or SG groups tended to be lower than those of F or S groups during the experimental time. The area under the curve(AUC) of C group was significantly highest among the groups, AUC and plasma insulin concentration of FG or SG groups tended to be lower than those of F or S groups. Plasma and hepatic triglyceride (TG) of FG and SG groups were significantly lower than those of F and S groups, plasma and hepatic total lipid(TL) and total cholesterol(TC) of FG and SG groups tended to be lower than those of F and S groups. Fecal TL, TG and TC of FG or SG groups tended to be higher than those of F and S groups. In conclusion, intake of guar gum should improve carbohydrate and lipid metabolism in partial substitution of fructose or sucrose for cornstarch in GK rats.

키워드

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