Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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Effect of Propolis Feeding on Rat Tissues Damaged by X-ray Irradiation

프로폴리스 섭식이 X-선에 의해 손상된 랫드의 여러 조직에 미치는 영향

  • Lee, Ji-Hoon (Department of Biological Science, Andong National University) ;
  • Ji, Tae-Jeong (Department of Radiological Science, Kaya University) ;
  • Seo, Eul-Won (Department of Biological Science, Andong National University)
  • 이지훈 (안동대학교 자연과학대학 생명과학과) ;
  • 지태정 (가야대학교 방사선학과) ;
  • 서을원 (안동대학교 자연과학대학 생명과학과)
  • Published : 2007.06.30
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Abstract

Present study aimed to investigate the radioprotective effects of propolis feeding on rat tissues damaged by X-ray irradiation. It was shown that the number of white blood cell in X-ray irradiated group supplemented with propolis increased as much to those of the control group and also the GOT activities among the blood components were decreased after propolis feeding. The mineral contents such as Mg, Fe, Ca, Mn, Cu, Mo, Ni, As in liver were increased as compared with those of the control group but maintained lower level than those of only irradiated groups, implying that the propolis feeding elevated the recovery capability of white blood cell effectively and propolis have a potential resistance to cell damage by X-ray. According to histological observations of the testis, intestine and liver tissues which are irradiated after feeding propolis, the numbers of damaged undifferentiated cells were decreased in testis and the shape of the goblet cells and inner and outer muscular layers in intestine were restored to the original state and the hepatocytes and interlobular veins were shown intact in liver, suggesting that propolis has a potential capacity to restore cell shapes or resist deformation of cell.

본 연구는 프로폴리스가 방사선에 조사된 랫드의 여러 조직에 미치는 방사선 방어 효과를 조사하였다. 혈장성분 중 백혈구의 수는 방사선 조사 20일 경과 후에 방사선만 조사한 실험군보다 프로폴리스 섭식 실험군에서 높은 증가를 나타냈으며, 혈장 성분 중 GOT의 활성도는 GPT에 비해 낮아지고 있다. 간 조직 내 미량원소 중 Mg, Fe, Ca, Mn, Cu, Mo, Ni, As의 함량은 대조 군에 비해서는 증가하였으나 방사선만 조사한 실험군에 비해서는 낮은 수준을 유지하고 있다. 즉 프로폴리스는 백혈구 수의 회복에 효과적이며 방사선으로 인한 간세포의 손상을 보호해 줌으로서 미량원소의 방출을 억제하고 GOT의 활성을 낮춰주는 것으로 생각된다. 조직학적으로 방사선조사 전에 프로폴리스를 섭식하면 정소에서는 훼손된 미분화 세포의 수가 감소하였고, 소장에서도 손상된 배상세포와 점막근판 조직의 형태가 부분적으로 정상적인 형태를 갖추는 것으로 관찰되었다. 따라서 프로폴리스의 섭식은 방사선으로부터 직접적으로 조직을 보호하거나 훼손된 세포의 회복에 영향을 미치는 것으로 조사되었다.

Keywords

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