Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Synergism in Antifungal Activity against Candida and Trichophyton Species in Combination with the Essential Oil of Coriandrum sativum L. and Antibiotics

  • Lim, Sook (College of Pharmacy, Duksung Women's University) ;
  • Shin, Seung-Won (College of Pharmacy, Duksung Women's University)
  • Published : 2007.03.31
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Abstract

To determine whether the essential oil from Coriandum sativum and its main component, linalool, exhibit antifungal activity, we employed a broth dilution assay and disk diffusion test using common pathogenic Candida and Trichophyton species. Both coriander oil and linalool significantly inhibited growth of the tested fungi, with minimal inhibitory concentrations (MICs) in the range of $0.03{\sim}2mg/ml$. Furthermore, in a checkerboard titer test, both the oil fraction and linalool exhibited synergism when combined with ketoconazole, with resultant FICIs ranging from 0.06 to 0.53. Notably, hyphal formation in C. albicans cells was obviously inhibited by C. sativum essential oil in this experiment.

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References

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