Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Administration of Aqueous Extract of Schizandra chinensis Fruit Inhibits the Experimental Colitis in Mice

  • Kang, Chon-Sik (Department of Immunology, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Tae, Jin (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Ham, Seong-Ho (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim, Dae-Ki (Department of Immunology, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee, Kang-Soo (Facuty of Biological Resources Science, Chonbuk National University) ;
  • Yun, Yong-Gab (Department of Prescription, Wonkwang University School of Oriental Medicine)
  • Published : 2007.03.31
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Abstract

Schizandra chinensis fruits (SC) have been used as a traditional Oriental medicine for treatments of many stress-induced diseases. In the present study, we investigated the protective effect of SC aqueous extract(SC-Ex) in the inflammatory diseases of intestine using a mouse model of ulcerative colitis. An experimental colitis was induced by daily treatment with 5% dextran sulfate sodium (DSS). SC-Ex was orally administered from day 2 of DSS treatment in a dose-dependent manner. Administration of SC-Ex reduced significantly clinic signs of DSS-induced colitis, including body weight loss, shorten colon length, increased disease activity index, and histological colon injury. Moreover, SC-Ex suppressed significantly not only the activities of myeloperoxidase (MPO) and chymase, but also the expressions of $TNF-{\acute{a}}$ and COX-2 in DSS-treated colon tissues. Inhibitory effect of SC-Ex was effective at a dose over 20 mg/kg. Our results indicate that SC-Ex may possess therapeutic effect on the development of DSS-induced colitis.

Keywords

References

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