Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitory Effect of Bacopa monniera on morphine Induced Pharmacological Effects in Mice

  • Published : 2007.03.31
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Abstract

The effects of the alcoholic extract of Bacopa monniera (BMA) on morphine-induced pharmacological activities were studied in mice. Oral administration of the extract (40 mg/kg) significantly inhibited morphine-induced analgesic tolerance, withdrawal symptoms, hyperactivity, reverse tolerance, Dopamine receptor supersensitivity and apo-morphine-induced climbing behaviour in mice. The results of this study showed that, alcoholic extract of Bacopa monniera (BMA) exerted inhibitory effect against morphine-induced pharmacological effects, suggesting that the extract could be useful in the treatment of morphine toxicity.

Keywords

References

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