Korean Journal of Poultry Science (한국가금학회지)

The Korean Society of Poultry Science (한국가금학회)
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Recent Molecular Studies of Marek's Disease Virus and Control Approaches for Increasing Virulence

마렉병 바이러스의 분자적 병리기전과 증가하는 병원성에 대한 제어 방안

  • Jang, H.K. (Department of Infectious Diseases and Avian Diseases, Colleage of Vertinary Medicine, Chonbuk National University) ;
  • Park, Y.M. (Department of Infectious Diseases and Avian Diseases, Colleage of Vertinary Medicine, Chonbuk National University) ;
  • Cha, S.Y. (Department of Infectious Diseases and Avian Diseases, Colleage of Vertinary Medicine, Chonbuk National University) ;
  • Kwon, J.T. (Department of Broiler Breeder, Halim Co. LTD)
  • 장형관 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 박영명 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 차세연 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 권정택 ((주)하림 제1본부 종계사업부)
  • Published : 2007.03.31
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Abstract

Marek's disease (MD) is caused by a ubiquitous, lymphotropic alphaherpesvirus, MD virus (MDV). MD has been a major concern in the poultry industry due to the emergence of increasingly virulent strains over the last few decades that were isolated in the face of comprehensive vaccination. MD is characterized by a variety of clinical signs, amongst them neurological symptoms, chronic wasting, and most notably the development of multiple lymphomas that manifest as solid tumors in the viscera and musculature. Much work has been devoted to study MD-induced oncogenesis and genes involved in this process. Among the many genes encoded by MDV, a number have recently been shown to affect the development of tumors in chickens, one protein directly causing transformation of cells (Meq) and another being involved in maintaining transformed cells (vTR). Other MDV gene products modulate and are involved in early lytic in vivo replication, thereby increasing the chance of transformation occurring. In this review, specific genes encoded by MDV that are involved in the initiation and/or maintenance of transformation were briefly summarized, and limits of current vaccination and new control strategies against MD, particularly how modem molecular biological methods may be used to improve strategies to combat the disease in the future, were discussed.

Keywords

References

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