Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Detection of Neuronal Activity by Motion Encoding Gradients: A Snail Ganglia Study

  • Park, Tae-S. (Dept. of Biomedical Engineering, Kyung Hee University) ;
  • Park, Ji-Ho (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Cho, Min-H. (Dept. of Biomedical Engineering, Kyung Hee University) ;
  • Lee, Soo-Y. (Dept. of Biomedical Engineering, Kyung Hee University)
  • Published : 2007.02.28
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Abstract

Presuming that firing neurons have motions inside the MRI magnet due to the interaction between the neuronal magnetic field and the main magnetic field, we applied motion encoding gradients to dissected snail ganglia to observe faster responding MRI signal than the BOLD signal. To activate the snail ganglia in synchronization with the MRI pulse sequence, we used electrical stimulation with the frequency of 30 Hz and the pulse width of 2s. To observe the fast responding signal, we used the volume selected MRI sequence. The magnetic resonance signal intensity, measured with 8 ms long motion encoding gradient with a 20mT/m gradient strength, decreased about $3.46{\pm}1.48%$ when the ganglia were activated by the electrical stimulation.

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References

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