Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Effects of Endothelin A Receptor Antagonist BQ123 on Femoral Artery Pressure and Pulmonary Artery Pressure in Broiler Chickens

  • Wang, Huiyu (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University) ;
  • Qiao, Jian (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University) ;
  • Gao, Mingyu (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University) ;
  • Yang, Ying (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University) ;
  • Li, Kai (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University) ;
  • Wang, Jianlin (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University) ;
  • Tian, Yong (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University) ;
  • Xu, Tong (Department of Animal Physiopathology, College of Veterinary Medicine China Agricultural University)
  • Received : 2006.10.11
  • Accepted : 2007.04.16
  • Published : 2007.10.01
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Abstract

Endothelin-1 (ET-1) is an important factor in regulation of cardiovascular tone in humans and mammals, but the biological function of ET-1 in the avian vascular system has not been determined. The purpose of this study was to characterize the role of endogenous ET-1 in the vascular system of poultry by investigating the effect of endothelin A receptor ($ET_AR$) antagonist BQ123 on the femoral artery pressure (FAP) and the pulmonary artery pressure (PAP) in broiler chickens. First, we found that plasma and lung homogenate ET-1 levels were both increased with age over the seven weeks life cyccle of broiler chickens. Second, 60 min after intravenous injection, BQ123 ($0.4{\mu}g\;kg^{-1}$ and $2.0{\mu}g\;kg^{-1}$, respectively) induced a significant reduction in FAP and PAP (p<0.05). Third, chronic infusion of BQ123 ($2.0{\mu}g\;kg^{-1}$ each time, two times a day) into abdominal cavities led to significant decrease in systolic pressure of the femoral (p<0.05) and pulmonary arteries (p<0.01) in broiler chickens at 7 and 14 days after treatment. Taken together, the $ET_AR$ antagonist BQ123 lead to a significant reduction of FAP and PAP, which suggests that endogenous ET-1 may be involved in the maintenance and regulation of systemic and pulmonary pressure in broiler chickens.

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References

  1. Apostolopoulou, S. C., S. Rammos, Z. S. Kyriakides, D. J. Webb, N. R. Johnston, D. V. Coddinos and D. Th. Kremastinos. 2003. Acute endothelin A receptor antagonism improves pulmonary arterial hypertension that is primary or autoimmune and related to congenital heart disease. Heart 89:1221-1226. https://doi.org/10.1136/heart.89.10.1221
  2. Battistelli, S., G. Manasse, R. Gaudio, T. Borgogni and S. Forconi. 1996. Circulating endothelin immunoreactivity in the elderly. Clin. Haemorheol. 16:653-660.
  3. Bigaud, M. and J. T. Pelron. 1992. Discrimination between ETAand ETB-receptor-mediated effects of endothelin-1 and [$Ala^{1, 3,11, 15}$] endothelin-1 by BQ123 in the anaesthetized rat. Br. J. Pharmacol. 107:912-918. https://doi.org/10.1111/j.1476-5381.1992.tb13385.x
  4. Bo, H., Y. Soonseek, H. Hongryul and W. Xiaolong. 2004. Effect of L-arginine on endothelium derived factors and cyclic nucleotides in broilers under low ambient temperature. Asian-Aust. J. Anim. Sci. 17:1570-1574. https://doi.org/10.5713/ajas.2004.1570
  5. Bo, H., Y. Soonseek, H. Hongryul, Q. Weijie and N. Fikru. 2005. Effect of low ambient temperature on the concentration of free radicals related to ascites in broiler chickens. Asian-Aust. J. Anim. Sci. 18:1182-1187. https://doi.org/10.5713/ajas.2005.1182
  6. Ferri, C., C. Bellini, D. C. Angelis, L. D. Siati, A. Perrone, G. Properzi and A. Santucci. 1995. Circulating endothelin-1 concentrations in patients with chronic hypoxia. J. Clin. Pathol. 48:519-524. https://doi.org/10.1136/jcp.48.6.519
  7. Galie, N., A. Manes and A. Branzi. 2004. The endothelin system in pulmonary arterial hypertension. Cardiovasc. Res. 61:227-237. https://doi.org/10.1016/j.cardiores.2003.11.026
  8. Gratton, J. P., G. Cournoyer, B. M. Loffler, P. Sirois and D. J. Pedro. 1997. ETB receptor and nitric oxide synthase blockade induce BQ-123-sensitive pressor effects in the rabbit. Hypertension 30:1204-1209. https://doi.org/10.1161/01.HYP.30.5.1204
  9. Guthrie, A. J., J. A. Cilliers, F. W. Huchzermeyer and V. M. Killeen. 1987. Broiler pulmonary hypertension syndrome. II. The direct measurement of right ventricular and pulmonary artery pressures in the closed chest domestic fowl. Onderstepoort J. Vet. Res. 54:599-602.
  10. Haynes, W. G., C. J. Ferro, K. P. O'Kane, D. Somerville, C. C. Lomax and D. J. Webb. 1996. Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans. Circulation 93:1860-1870. https://doi.org/10.1161/01.CIR.93.10.1860
  11. Haynes, W. G. and D. J. Webb. 1994. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 344:852-854. https://doi.org/10.1016/S0140-6736(94)92827-4
  12. Inoue, A., M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto and T. Masaki. 1989. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. 86:2863-2867. https://doi.org/10.1073/pnas.86.8.2863
  13. Ipek, A. and U. Saha. 2006. Effect of cold stress on broiler performance and ascites susceptibility. Asian-Aust. J. Anim. Sci. 19:734-738. https://doi.org/10.5713/ajas.2006.734
  14. Kai, L., Q. Jian, Z. Lihong, D. Shishan, O. Deyuan, W. Jianlin, W. Huiyu and X. Tong. 2006. Increased calcium deposits and decreased $Ca^{2+}$-ATPase in right ventricular myocardium of ascitic broiler chickens. J. Vet. Med. A.53:458-463. https://doi.org/10.1111/j.1439-0442.2006.00856.x
  15. Kempf, H., C. Linares, P. Corvol and J. M. Gasc. 1998. Pharmacological inactivation of the endothelin type A receptor in the early chick embryo: a model of mispatterning of the branchial arch derivatives. Develop. 125:4931-4941.
  16. Langleben, D., R. J. Barst, D. Badesch, B. M. Groves, V. F. Tapson, S. Murali, R. C. Bourge, N. Ettinger, E. Shalit, L. Clayton, M. M. Jobsis, S. D. Blackburn, J. W. Crow, D. J. Stewart and W. Long. 1999. Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertension. Circulation 99:3266-3271. https://doi.org/10.1161/01.CIR.99.25.3266
  17. Langouche, L., I. Vanhorebeek, D. Vlasselaers, S. V. Perre, P. J. Wouters, K. Skogstrand, T. K. Hansen and G. V. Berghe. 2005. Intensive insulin therapy protects the endothelium of critically ill patients. J. Clin. Invest. 115:2277-2287. https://doi.org/10.1172/JCI25385
  18. Levin, E. R. 1995. Endothelins. N. Engl. J. Med. 333:356-363. https://doi.org/10.1056/NEJM199508103330607
  19. Mukai, Y., Y. Rikitake, I. Shiojima, S. Wolfrum, M. Satoh, K. Takeshita, Y. Hiroi, S. Salomone, H. H. S., Kim, L. E. Benjamin, K. Walsh and J. K. Liao, J. K. 2006. Decreased vascular lesion formation in mice with inducible endothelialspecific expression of protein kinase Akt. J. Clin. Invest. 116:334-344. https://doi.org/10.1172/JCI26223
  20. Ronald, G. T., L. M. Christy, J. S. Sidney, C. Shijuan, C. Yiufai, W. Chengda, B. R. Natalie, A. F. D. Richard and A. B. Tommy. 2000. Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active $ET_A$ receptor antagonist. Pulm. Pharmacol. Ther. 13:87-97. https://doi.org/10.1006/pupt.2000.0237
  21. Sakurai, T., M. Yanagisawa and T. Masaki. 1992. Molecular characterization of endothelin receptors. Trends. Pharmacol. Sci. 13:103-108. https://doi.org/10.1016/0165-6147(92)90038-8
  22. Takahashi, T., T. Kanda, M. Inoue, H. Sumino, I. Kobayashi, A. Iwamoto and R. Nagai. 1998. Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension. Life Sci. 63:137-143.
  23. Watanabe, H., H. Miyazaki, M. Kondoh, Y. Masuda, S. Kimura, M. Yamagisawa, T. Masaki and K. Murakami. 1989. Two distinct types of endothelin receptors are present on chick cardiac membranes. Biochem. Biophys. Res. Commun.161:1252-1259. https://doi.org/10.1016/0006-291X(89)91377-6
  24. Willtte, R. N., E. H. Ohlstein, M. P. Mitchell, C. F. Sauermelch, G. R. Beck, M. A. Luttmann and D. W. P. Hay. 1997. Nonpeptide endothelin receptor antagonists: VIII, Attenuation of acute hypoxia-induced pulmonary hypertension in the dog. J. Pharmacol. Exp. Ther. 250:695-701.
  25. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto and T. Masak. 1988. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415. https://doi.org/10.1038/332411a0
  26. Yanagisawa, M. and T. Masaki. 1989. Endothelin, a novel endothelium-derived peptide, pharmacological activities, regulation and possible roles in cardiovascular control. Biochem. Pharmacol. 38:1877-1883. https://doi.org/10.1016/0006-2952(89)90484-X
  27. Ying, Y., Q. Jian, W. Zhenlong, C. Yue, G. Mingyu, O. Deyuan and W. Huiyu. 2005. Endothelin-1 receptor antagonist BQ123 prevents pulmonary artery hypertension induced by low ambient temperature in broilers. Biol. Pharm. Bull. 28:2201-2205. https://doi.org/10.1248/bpb.28.2201