참고문헌
- Arai, E., Kanai, Y., Ushijima, S., Fujimoto, H., Mukai, K. and Hirohashi, S. (2006) Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues. Int. J. Cancer 119, 288-296. https://doi.org/10.1002/ijc.21807
- Baylin, S. B. and Ohm, J. E. (2006) Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer 6, 107-116. https://doi.org/10.1038/nrc1799
- Braakhuis, B. J., Tabor, M. P., Kummer, J. A., Leemans, C. R. and Brakenhoff, R. H. (2003) A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res. 63, 1727-1730.
- Chan, A. O., Lam, S. K., Wong, B. C., Wong, W. M., Yuen, M. F., Yeung, Y. H., Hui, W. M., Rashid, A. and Kwong, Y. L. (2003) Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut 52, 502-506. https://doi.org/10.1136/gut.52.4.502
- Chan, A. O., Peng, J. Z., Lam, S. K., Lai, K. C., Yuen, M. F., Cheung, H. K., Kwong, Y. L., Rashid, A., Chan, C. K. and Wong, B. C. (2006) Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation. Gut 55, 463-468. https://doi.org/10.1136/gut.2005.077776
- Copper, M. P., Braakhuis, B. J., de Vries, N., van Dongen, G. A., Nauta, J. J. and Snow, G. B. (1993) A panel of biomarkers of carcinogenesis of the upper aerodigestive tract as potential intermediate endpoints in chemoprevention trials. Cancer 71, 825-830. https://doi.org/10.1002/1097-0142(19930201)71:3<825::AID-CNCR2820710327>3.0.CO;2-X
- Csiszar, K., Fong, S. F., Ujfalusi, A., Krawetz, S. A., Salvati, E. P., Mackenzie, J. W. and Boyd, C. D. (2002) Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors. Int. J. Cancer 97, 636-642. https://doi.org/10.1002/ijc.10035
- de Smet, C., Lurquin, C., Lethe, B., Martelange, V. and Boon, T. (1999) DNA methylation is the primary silencing mechanism for a set of germ line-and tumor-specific genes with a CpGrich promoter. Mol. Cell. Biol. 19, 7327-7335. https://doi.org/10.1128/MCB.19.11.7327
- de Smet, C., Loriot, A. and Boon, T. (2004) Promoter-dependent mechanism leading to selective hypomethylation within the 5' region of gene MAGE-A1 in tumor cells. Mol. Cell. Biol. 24, 4781-4790. https://doi.org/10.1128/MCB.24.11.4781-4790.2004
- Eads, C. A., Lord, R. V., Kurumboor, S. K., Wickramasinghe, K., Skinner, M. L., Long, T. I., Peters, J. H., DeMeester, T. R., Danenberg, K. D., Danenberg, P. V., Laird, P. W. and Skinner, K. A. (2000) Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res. 60, 5021-5026.
- Eden, A., Gaudet, F., Waghmare, A. and Jaenisch, R. (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300, 455. https://doi.org/10.1126/science.1083557
- Ekstrom, A. M., Held, M., Hansson, L. E., Engstrand, L. and Nyren, O. (2001) Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterol. 121, 784-791. https://doi.org/10.1053/gast.2001.27999
- El-Omar, E. M., Carrington, M., Chow, W. H., McColl, K. E., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C. C., Rothman, N., Lanyon, G., Martin, M., Fraumeni, J. F., Jr. and Rabkin, C. S. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404, 398-402. https://doi.org/10.1038/35006081
- Furuta, J., Nobeyama, Y., Umebayashi, Y., Otsuka, F., Kikuchi, K. and Ushijima, T. (2006) Silencing of peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res. 66, 6080- 6086. https://doi.org/10.1158/0008-5472.CAN-06-0157
- Gotoda, T., Yamamoto, H. and Soetikno, R. M. (2006) Endoscopic submucosal dissection of early gastric cancer. J. Gastroenterol. 41, 929-942. https://doi.org/10.1007/s00535-006-1954-3
- Guo, M., House, M. G., Hooker, C., Han, Y., Heath, E., Gabrielson, E., Yang, S. C., Baylin, S. B., Herman, J. G. and Brock, M. V. (2004) Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clin. Cancer Res. 10, 5131-5136. https://doi.org/10.1158/1078-0432.CCR-03-0763
- Hafner, C., Knuechel, R., Stoehr, R. and Hartmann, A. (2002) Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies. Int. J. Cancer 101, 1-6. https://doi.org/10.1002/ijc.10544
- Hsieh, C. J., Klump, B., Holzmann, K., Borchard, F., Gregor, M.and Porschen, R. (1998) Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with longstanding and extensive ulcerative colitis. Cancer Res. 58, 3942- 3945.
- Issa, J. P., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E. and Baylin, S. B. (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet. 7, 536-540. https://doi.org/10.1038/ng0894-536
- Issa, J. P., Ahuja, N., Toyota, M., Bronner, M. P. and Brentnall, T. A. (2001) Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res. 61, 3573-3577.
- Kaneda, A., Kaminishi, M., Yanagihara, K., Sugimura, T. and Ushijima, T. (2002) Identification of silencing of nine genes in human gastric cancers. Cancer Res. 62, 6645-6650.
- Kaneda, A., Takai, D., Kaminishi, M., Okochi, E. and Ushijima, T. (2003) Methylation-sensitive representational difference analysis and its application to cancer research. Ann. N. Y. Acad. Sci. 983, 131-141. https://doi.org/10.1111/j.1749-6632.2003.tb05968.x
- Kaneda, A., Tsukamoto, T., Takamura-Enya, T., Watanabe, N., Kaminishi, M., Sugimura, T., Tatematsu, M. and Ushijima, T. (2004a) Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci. 95, 58-64. https://doi.org/10.1111/j.1349-7006.2004.tb03171.x
- Kaneda, A., Wakazono, K., Tsukamoto, T., Watanabe, N., Yagi, Y., Tatematsu, M., Kaminishi, M., Sugimura, T. and Ushijima, T. (2004b) Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res. 64, 6410-6415. https://doi.org/10.1158/0008-5472.CAN-04-1543
- Kang, G. H., Lee, H. J., Hwang, K. S., Lee, S., Kim, J. H. and Kim, J. S. (2003) Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am. J. Pathol. 163, 1551-1556. https://doi.org/10.1016/S0002-9440(10)63511-0
- Kondo, Y., Kanai, Y., Sakamoto, M., Mizokami, M., Ueda, R. and Hirohashi, S. (2000) Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 32, 970-979. https://doi.org/10.1053/jhep.2000.19797
- Laird, C. D., Pleasant, N. D., Clark, A. D., Sneeden, J. L., Hassan, K. M., Manley, N. C., Vary, J. C., Jr., Morgan, T., Hansen, R. S. and Stoger, R. (2004) Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proc. Natl. Acad. Sci. USA 101, 204-209. https://doi.org/10.1073/pnas.2536758100
- Lee, K. A., Ki, C. S., Kim, H. J., Sohn, K. M., Kim, J. W., Kang, W. K., Rhee, J. C., Song, S. Y. and Sohn, T. S. (2004) Novel interleukin 1beta polymorphism increased the risk of gastric cancer in a Korean population. J. Gastroenterol. 39, 429-433. https://doi.org/10.1007/s00535-003-1315-4
- Lee, K. J., Inoue, M., Otani, T., Iwasaki, M., Sasazuki, S. and Tsugane, S. (2006) Gastric cancer screening and subsequent risk of gastric cancer: a large-scale population-based cohort study, with a 13-year follow-up in Japan. Int. J. Cancer 118, 2315-2321. https://doi.org/10.1002/ijc.21664
- Li, E. (2002) Chromatin modification and epigenetic reprogramming in mammalian development. Nat. Rev. Genet. 3, 662-673. https://doi.org/10.1038/nrg887
- Li, Q. L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X. Z., Lee, K. Y., Nomura, S., Lee, C. W., Han, S. B., Kim, H. M., Kim, W. J., Yamamoto, H., Yamashita, N., Yano, T., Ikeda, T., Itohara, S., Inazawa, J., Abe, T., Hagiwara, A., Yamagishi, H., Ooe, A., Kaneda, A., Sugimura, T., Ushijima, T., Bae, S. C. and Ito, Y. (2002) Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109, 113-124. https://doi.org/10.1016/S0092-8674(02)00690-6
- Maekita, T., Nakazawa, K., Mihara, M., Nakajima, T., Yanaoka, K., Iguchi, M., Arii, K., Kaneda, A., Tsukamoto, T., Tatematsu, M., Tamura, G., Saito, D., Sugimura, T., Ichinose, M. and Ushijima, T. (2006) High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin. Cancer Res. 12, 989-995. https://doi.org/10.1158/1078-0432.CCR-05-2096
- Mihara, M., Yoshida, Y., Tsukamoto, T., Inada, K., Nakanishi, Y., Yagi, Y., Imai, K., Sugimura, T., Tatematsu, M. and Ushijima, T. (2006) Methylation of multiple genes in gastric glands with intestinal metaplasia: a disorder with polyclonal origins. Am. J. Pathol. 169, 1643-1651. https://doi.org/10.2353/ajpath.2006.060552
- Min, C., Kirsch, K. H., Zhao, Y., Jeay, S., Palamakumbura, A. H., Trackman, P. C. and Sonenshein, G. E. (2007) The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer. Cancer Res. 67, 1105-1112. https://doi.org/10.1158/0008-5472.CAN-06-3867
- Miyamoto, K., Asada, K., Fukutomi, T., Okochi, E., Yagi, Y., Hasegawa, T., Asahara, T., Sugimura, T. and Ushijima, T. (2003) Methylation-associated silencing of heparan sulfate Dglucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. Oncogene 22, 274-280. https://doi.org/10.1038/sj.onc.1206146
- Miyazaki, M., Ohno, S., Futatsugi, M., Saeki, H., Ohga, T. and Watanabe, M. (2002) The relation of alcohol consumption and cigarette smoking to the multiple occurrence of esophageal dysplasia and squamous cell carcinoma. Surgery 131, 7-13. https://doi.org/10.1067/msy.2002.119288
- Nagao, M., Ochiai, M., Okochi, E., Ushijima, T. and Sugimura, T. (2001) LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences. Mutat. Res. 477, 119-124. https://doi.org/10.1016/S0027-5107(01)00113-0
- Nakajima, T., Oda, I., Gotoda, T., Hamanaka, H., Eguchi, T., Yokoi, C. and Saito, D. (2006a) Metachronous gastric cancers after endoscopic resection: how effective is annual endoscopic surveillance? Gastric Cancer 9, 93-98. https://doi.org/10.1007/s10120-006-0372-9
- Nakajima, T., Maekita, T., Oda, I., Gotoda, T., Yamamoto, S., Umemura, S., Ichinose, M., Sugimura, T., Ushijima, T. and Saito, D. (2006b) Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers Cancer Epidemiol. Biomarkers Prev. 15, 2317-2321. https://doi.org/10.1158/1055-9965.EPI-06-0436
- Ohtani-Fujita, N., Fujita, T., Aoike, A., Osifchin, N. E., Robbins, P. D. and Sakai, T. (1993) CpG methylation inactivates the promoter activity of the human retinoblastoma tumorsuppressor gene. Oncogene 8, 1063-1067.
- Partridge, M., Pateromichelakis, S., Phillips, E., Emilion, G. G., A'Hern, R. P. and Langdon, J. D. (2000) A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization. Cancer Res. 60, 3893-3898.
- Ren, C., Yang, G., Timme, T. L., Wheeler, T. M. and Thompson, T. C. (1998) Reduced lysyl oxidase messenger RNA levels in experimental and human prostate cancer. Cancer Res. 58, 1285-1290.
- Richards, E. J. and Elgin, S. C. (2002) Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 108, 489-500. https://doi.org/10.1016/S0092-8674(02)00644-X
- Riggs, A. D. and Xiong, Z. (2004) Methylation and epigenetic fidelity. Proc. Natl. Acad. Sci. USA 101, 4-5. https://doi.org/10.1073/pnas.0307781100
- Robertson, K. D. (2005) DNA methylation and human disease. Nat. Rev. Genet. 6, 597-610.
- Shen, L., Kondo, Y., Rosner, G. L., Xiao, L., Hernandez, N. S., Vilaythong, J., Houlihan, P. S., Krouse, R. S., Prasad, A. R., Einspahr, J. G., Buckmeier, J., Alberts, D. S., Hamilton, S. R. and Issa, J. P. (2005) MGMT promoter methylation and field defect in sporadic colorectal cancer. J. Natl. Cancer Inst. 97, 1330-1338. https://doi.org/10.1093/jnci/dji275
- Slaughter, D. P., Southwick, H. W. and Smejkal, W. (1953) Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6, 963-968. https://doi.org/10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q
- Song, J. Z., Stirzaker, C., Harrison, J., Melki, J. R. and Clark, S. J. (2002) Hypermethylation trigger of the glutathione-Stransferase gene (GSTP1) in prostate cancer cells. Oncogene 21, 1048-1061. https://doi.org/10.1038/sj.onc.1205153
- Sozzi, G., Miozzo, M., Pastorino, U., Pilotti, S., Donghi, R., Giarola, M., De Gregorio, L., Manenti, G., Radice, P., Minoletti, F., Porta, G. D. and Pierotti, M. A. (1995) Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions. Cancer Res. 55, 135-140.
- Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N.,Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N. and Schlemper, R. J. (2001) Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345, 784-789. https://doi.org/10.1056/NEJMoa001999
- Ushijima, T., Morimura, K., Hosoya, Y., Okonogi, H., Tatematsu, M., Sugimura, T. and Nagao, M. (1997) Establishment of methylation-sensitive-representational difference analysis and isolation of hypo-and hypermethylated genomic fragments in mouse liver tumors. Proc. Natl. Acad. Sci. USA 94, 2284-2289. https://doi.org/10.1073/pnas.94.6.2284
- Ushijima, T., Watanabe, N., Okochi, E., Kaneda, A., Sugimura, T. and Miyamoto, K. (2003) Fidelity of the methylation pattern and its variation in the genome. Genome Res. 13, 868-874. https://doi.org/10.1101/gr.969603
- Ushijima, T. and Sasako, M. (2004) Focus on gastric cancer. Cancer Cell 5, 121-125. https://doi.org/10.1016/S1535-6108(04)00033-9
- Ushijima, T. (2005) Detection and interpretation of altered methylation patterns in cancer cells. Nat. Rev. Cancer 5, 223- 231. https://doi.org/10.1038/nrc1571
- Ushijima, T., Nakajima, T. and Maekita, T. (2006) DNA methylation as a marker for the past and future. J. Gastroenterol. 41, 401-407. https://doi.org/10.1007/s00535-006-1846-6
- Waki, T., Tamura, G., Tsuchiya, T., Sato, K., Nishizuka, S. and Motoyama, T. (2002) Promoter methylation status of Ecadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am. J. Pathol. 161, 399-403. https://doi.org/10.1016/S0002-9440(10)64195-8
- Wistuba, I. I., Lam, S., Behrens, C., Virmani, A. K., Fong, K. M., LeRiche, J., Samet, J. M., Srivastava, S., Minna, J. D. and Gazdar, A. F. (1997) Molecular damage in the bronchial epithelium of current and former smokers. J. Natl. Cancer Inst. 89, 1366-1373. https://doi.org/10.1093/jnci/89.18.1366
- Yamashita, S., Tsujino, Y., Moriguchi, K., Tatematsu, M. and Ushijima, T. (2006) Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5- aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 97, 64-71. https://doi.org/10.1111/j.1349-7006.2006.00136.x
- Yan, P. S., Venkataramu, C., Ibrahim, A., Liu, J. C., Shen, R. Z., Diaz, N. M., Centeno, B., Weber, F., Leu, Y. W., Shapiro, C. L., Eng, C., Yeatman, T. J. and Huang, T. H. (2006) Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clin. Cancer Res. 12, 6626-6636. https://doi.org/10.1158/1078-0432.CCR-06-0467
- Yoo, C. B. and Jones, P. A. (2006) Epigenetic therapy of cancer:past, present and future. Nat. Rev. Drug Discov. 5, 37-50. https://doi.org/10.1038/nrd1930
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- Role of Stromal-Epithelial Interaction in the Formation and Development of Cancer Cells vol.6, pp.3, 2013, https://doi.org/10.1007/s12307-013-0131-5
- Frequent involvement of chromatin remodeler alterations in gastric field cancerization vol.357, pp.1, 2015, https://doi.org/10.1016/j.canlet.2014.11.038
- XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis vol.11, pp.6, 2010, https://doi.org/10.1111/j.1751-2980.2010.00459.x
- Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction vol.31, pp.3, 2012, https://doi.org/10.1038/onc.2011.241
- Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection vol.15, pp.4, 2012, https://doi.org/10.1007/s10120-011-0126-1
- SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer vol.229, pp.1, 2013, https://doi.org/10.1002/path.4078
- DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status vol.2, pp.3, 2010, https://doi.org/10.2217/epi.10.16
- DNA methylation profiling: a promising tool and a long road ahead for clinical applications vol.65, pp.12, 2011, https://doi.org/10.1111/j.1742-1241.2011.02804.x
- DNA methylation-based biomarkers in serum of patients with breast cancer vol.751, pp.2, 2012, https://doi.org/10.1016/j.mrrev.2012.06.001
- Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae vol.32, pp.4, 2015, https://doi.org/10.1007/s12032-015-0571-5
- Epigenetic dysregulation of the host cell genome in Epstein–Barr virus-associated neoplasia vol.19, pp.3, 2009, https://doi.org/10.1016/j.semcancer.2009.02.012
- Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) vol.40, pp.3, 2010, https://doi.org/10.3109/10408440903384717
- Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age vol.9, pp.4, 2014, https://doi.org/10.4161/epi.27650
- Epigenetic alterations due to diet andHelicobacter pyloriinfection in gastric carcinogenesis vol.2, pp.2, 2008, https://doi.org/10.1586/17474124.2.2.243
- LINE-1 Hypomethylation in Noncancerous Esophageal Mucosae is Associated with Smoking History vol.19, pp.13, 2012, https://doi.org/10.1245/s10434-012-2488-y
- The adjacent to tumor sample trap vol.19, pp.3, 2016, https://doi.org/10.1007/s10120-015-0539-3
- DNA demethylation in normal colon tissue predicts predisposition to multiple cancers vol.31, pp.48, 2012, https://doi.org/10.1038/onc.2011.652
- Modifiable risk factors in periodontal disease vol.64, pp.1, 2014, https://doi.org/10.1111/prd.12000
- Microbe-induced epigenetic alterations in host cells: The coming era of patho-epigenetics of microbial infections vol.56, pp.1, 2009, https://doi.org/10.1556/AMicr.56.2009.1.1
- Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer vol.44, pp.10, 2014, https://doi.org/10.1007/s00595-013-0763-6
- Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma vol.342, pp.2, 2014, https://doi.org/10.1016/j.canlet.2012.01.038
- Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe–gastric epithelial cells cross-talk vol.202, pp.5, 2013, https://doi.org/10.1007/s00430-013-0301-6
- Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average-risk individuals vol.41, pp.1, 2015, https://doi.org/10.1111/apt.13003
- Genome-wide DNA methylation profiles in precancerous conditions and cancers vol.101, pp.1, 2010, https://doi.org/10.1111/j.1349-7006.2009.01383.x
- Frequent hypermethylation of DAPK, RARbeta, MGMT, RASSF1A and FHIT in laryngeal squamous cell carcinomas and adjacent normal mucosa vol.47, pp.2, 2011, https://doi.org/10.1016/j.oraloncology.2010.11.006
- Role of DNA methylation in head and neck cancer vol.2, pp.2, 2011, https://doi.org/10.1007/s13148-011-0045-3
- Potential usefulness of DNA methylation as a risk marker for digestive cancer associated with inflammation vol.12, pp.5, 2012, https://doi.org/10.1586/erm.12.38
- DNA methylation: a marker for carcinogen exposure and cancer risk vol.13, pp.1, 2008, https://doi.org/10.1007/s12199-007-0005-x
- Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression vol.28, pp.1, 2015, https://doi.org/10.1038/modpathol.2014.81
- DNA methylation accumulation and its predetermination of future cancer phenotypes vol.156, pp.2, 2014, https://doi.org/10.1093/jb/mvu038
- Role of Cytoskeleton in Controlling the Disorder Strength of Cellular Nanoscale Architecture vol.99, pp.3, 2010, https://doi.org/10.1016/j.bpj.2010.05.023
- Update on microbe-induced epigenetic changes: bacterial effectors and viral oncoproteins as epigenetic dysregulators vol.8, pp.11, 2013, https://doi.org/10.2217/fvl.13.97
- Epstein-Barr virus and gastric carcinoma: virus-host interactions leading to carcinoma vol.99, pp.9, 2008, https://doi.org/10.1111/j.1349-7006.2008.00888.x
- Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm vol.10, pp.2, 2016, https://doi.org/10.5009/gnl14472
- Epigenetic progenitors in tumor initiation and development vol.6, pp.1, 2009, https://doi.org/10.1016/j.ddmod.2009.01.001
- Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization vol.23, pp.6, 2012, https://doi.org/10.1007/s10552-012-9955-4
- Multifocal epithelial tumors and field cancerization: stroma as a primary determinant vol.124, pp.4, 2014, https://doi.org/10.1172/JCI72589
- Up-regulation of Activation-Induced Cytidine Deaminase Causes Genetic Aberrations at the CDKN2b-CDKN2a in Gastric Cancer vol.139, pp.6, 2010, https://doi.org/10.1053/j.gastro.2010.07.010
- Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon vol.41, pp.1, 2010, https://doi.org/10.1016/j.humpath.2009.06.002
- Interaction of Cigarette Exposure and Airway Epithelial Cell Gene Expression vol.73, pp.1, 2011, https://doi.org/10.1146/annurev-physiol-012110-142219
- Epstein-Barr virus and gastric carcinoma vol.60, pp.5, 2010, https://doi.org/10.1111/j.1440-1827.2010.02533.x
- ZIC1 is downregulated through promoter hypermethylation in gastric cancer vol.379, pp.4, 2009, https://doi.org/10.1016/j.bbrc.2008.12.180
- Melanoma update: diagnostic and prognostic factors that can effectively shape and personalize management vol.5, pp.3, 2011, https://doi.org/10.2217/bmm.11.39
- Cellular reprogramming technology for dissecting cancer epigenome in vivo vol.9, pp.7, 2017, https://doi.org/10.2217/epi-2017-0018
- Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance vol.54, pp.5, 2014, https://doi.org/10.1016/j.molcel.2014.05.015
- Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis vol.101, pp.6, 2010, https://doi.org/10.1111/j.1349-7006.2010.01535.x
- On the Stem Cell Origin of Cancer vol.176, pp.6, 2010, https://doi.org/10.2353/ajpath.2010.091064
- DNA methylation status of theIL8gene promoter in oral cells of smokers and non-smokers with chronic periodontitis vol.36, pp.9, 2009, https://doi.org/10.1111/j.1600-051X.2009.01446.x
- LINE-1 hypomethylation level as a potential prognostic factor for epithelial ovarian cancer vol.18, pp.4, 2008, https://doi.org/10.1111/j.1525-1438.2007.01117.x
- Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients vol.10, pp.1, 2010, https://doi.org/10.1186/1471-2407-10-97
- Cancer Stem Cells: Biological Functions and Therapeutically Targeting vol.15, pp.5, 2014, https://doi.org/10.3390/ijms15058169
- Hereditary diffuse gastric cancer and lost cell polarity: a short path to cancer vol.4, pp.2, 2008, https://doi.org/10.2217/14796694.4.2.229
- Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study vol.64, pp.3, 2015, https://doi.org/10.1136/gutjnl-2014-307094
- Epigenetics and Head and Neck Cancer vol.109, pp.9, 2016, https://doi.org/10.5631/jibirin.109.599
- Characterization of DNA hypermethylation in two cases of peritoneal mesothelioma vol.33, pp.6, 2012, https://doi.org/10.1007/s13277-012-0462-8
- Epigenetic biomarkers in the diagnosis of ovarian cancer vol.6, pp.5, 2012, https://doi.org/10.1517/17530059.2012.702105
- Reprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is Frequently Hypermethylated in Estrogen Receptor α-Positive Breast Cancer vol.18, pp.8, 2017, https://doi.org/10.3390/ijms18081525
- Epigenetic Events Associated with Breast Cancer and Their Prevention by Dietary Components Targeting the Epigenome vol.25, pp.1, 2012, https://doi.org/10.1021/tx200378c
- Colonic crypt organization and tumorigenesis vol.8, pp.6, 2008, https://doi.org/10.1038/nrc2392
- Impact of the epithelial dysplasia grading and Ki67 proliferation index in the adjacent non-malignant mucosa on recurrence and survival in head and neck squamous cell carcinoma vol.208, pp.11, 2012, https://doi.org/10.1016/j.prp.2012.08.002
- Genome-Wide DNA Methylation Profiles in Noncancerous Gastric Mucosae with Regard to Helicobacter pylori Infection and the Presence of Gastric Cancer vol.16, pp.3, 2011, https://doi.org/10.1111/j.1523-5378.2011.00838.x
- The presence of large serrated polyps increases the risk of colorectal cancer vol.123, pp.2, 2011, https://doi.org/10.4044/joma.123.97
- The causal relationship between epigenetic abnormality and cancer development: in vivo reprogramming and its future application vol.94, pp.6, 2018, https://doi.org/10.2183/pjab.94.016
- Paradoxical Roles of Oxidative Stress Response in the Digestive System before and after Carcinogenesis vol.11, pp.2, 2019, https://doi.org/10.3390/cancers11020213