The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 4
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- Pages.169-176
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Study on Antioxidant Effect of Lithospermi Radix on Liver Cells Isolated from Oxidatively Stressed Rat
산화동물모델 흰 쥐 간세포에 대한 자근(紫根)의 황산화 효과 연구
- Kim, Sung-Hyum (College of Oriental medicine, Kyungwon University) ;
-
Park, Wan-Su
(College of Oriental medicine, Kyungwon University)
;
-
Seong, Nak-Sull
(National Crop Experiment Station, RDA)
;
-
Lee, Young-Jong
(College of Oriental medicine, Kyungwon University)
- Published : 2007.12.31
Abstract
Objective : This study purposed to investigate the anti-oxidative effect of Lithospermi Radix (root of Lithospermum erythrorhizon S.) on liver cells isolated from oxidatvely stressed rat by AAPH. Method : We investigate effects of Lithospermi Radix(LR) and its fractions on normal liver cells' proliferation. And the amounts of SOD, GSH, catalase, NO, MDA production by liver cells isolated from the oxidatively stressed rat by AAPH also were measured after incubation with various fractions of LR extraction. Results : LR and its fracitons showed no toxicity on the normal liver cells from rat. LR and its fracitons increased the activity of SOD and reduced the amounts of NO and MDA in the liver cells from the oxidatively stressed rat. Conclusion : Lithospermi Radix could be supposed to have antioxidant effect on liver cells with no toxicity.