Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant Effect of Alisma plantago-aquatica var. orientale and Its Main Component

택사 메탄올 추출물과 주성분의 항산화작용

  • Kim, Se-Eun (Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University) ;
  • Rhyu, Dong-Young (Division of Bioscience, Mokpo National University) ;
  • Yokozawa, Takako (Institute of Natural Medicine, University of Toyama) ;
  • Park, Jong-Cheol (Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University)
  • 김세은 (순천대학교 한약자원학과 및 한의약연구소) ;
  • 류동영 (목포대학교 생명과학부 생약자원) ;
  • ;
  • 박종철 (순천대학교 한약자원학과 및 한의약연구소)
  • Published : 2007.12.31
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Abstract

Reactive oxygen species(ROS) or free radicals are produced in the pathogenesis of human diseases including atherosclerosis, diabetes, cancer, and aging. Antioxidants are associated with the prevention of ROS-induced tissue and cellular damage in the various diseases. This study investigated the antioxidative activities of the methanol extract of Alisma plantagoaquatica var. orientale and its main component under conditions of radical generation using allophycocyanin and ferric-thiocyanate assay. Alisol B 23-acetate as a main component was isolated from the methanol extract of Alisma plantago-aquatica var. orientale. In results, the extract of Alisma plantago-aquatica var. orientale showed inhibitory activity on AAPH [2,2'-azobis(2-amidinopropane)dihydrochloride]-induced protein oxidation. Also, the extract of Alisma plantago-aquatica var. orientale and alisol B 23-acetate inhibited lipid peroxidation. These results indicate that Alisma plantago-aquatica var. orientale and alisol B 23-acetate show promise as therapeutic agents for various damages involving free radical reactions.

Keywords

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