Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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In-vitro Anti-inflammatory Activity of Rubus coreanus Miq. on Nitric Oxide, $Interferon-\gamma$, Cycloxygenase-2, and Tumor Necrosis $Factor-\alpha$ Production in the Macrophage like Cell Line RAW 264.7 Activated by Lipopolysccharide

  • Choi, Se-Young (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Lee, Kyou-Chae (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Jeoung, Young-Jun (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
  • Published : 2007.10.31
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Abstract

To search for immunoactive natural products exerting anti-inflammatory activity, we have evaluated the effects of the ethanol extracts of Rubus coreanus Miq. (ERC) on lipopolysaccharide-induced nitric oxide (NO), tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$, and $Interferon-{\gamma}\;(IFN-{\gamma})$ production by RAW 264.7 macrophage cell line. Our data indicate that this extract is a potent inhibitor of NO production and it also significantly decreased $IFN-{\gamma}\;and\;TNF-{\alpha}$ production. Consistent with these results, the protein level of inducible Nitric Oxide Synthase (iNOS) and cyclooxygenase-2 (COX-2) was inhibited by ethanol extracts of ERC in a dose-dependent manner. These results suggest that ERC may exert anti-inflammatory and analgesic effects possibly by suppressing the inducible NO synthase and COX-2 expressions.

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References

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