Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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THE EFFECT OF PRP AND FIBRIN SEALANT WITH THE DEPROTENIZED BOVINE BONE IN THE RABBIT CRANIUM

가토의 두개골 골결손부에 탈단백 우골 이식시 혈소판 농축 혈장과 피브린 실란트의 효과

  • Lee, Yong-In (Dept. of Oral and Maxillofacial Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Seung-Yun (Dept. of Periodontics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Dong-Hwan (Dept. of Prosthodontics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hong, Jong-Rak (Dept. of Oral and Maxillofacial Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 이용인 (성균관대학교 의과대학 삼성서울병원 구강악안면외과) ;
  • 신승윤 (성균관대학교 의과대학 삼성서울병원 치주과) ;
  • 이동환 (성균관대학교 의과대학 삼성서울병원 보철과) ;
  • 홍종락 (성균관대학교 의과대학 삼성서울병원 구강악안면외과)
  • Published : 2007.06.30
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Abstract

Purpose The purpose of this study is to evaluation of effect on bone formation of PRP and fibrin sealant with deproteinized bovine bone(Bio-Oss) grafts on rabbit cranial defect. Material and Methods Twelve rabbits were used as experimental animal Two equal 9mm diameter cranial bone defects were created in each rabbit and immediately grafted with Bio-Oss only, Bio-Oss and PRP, and Bio-Oss and Fibrin sealant. Rabbits were sacrificed at 4 and 8 week. The defects were evaluated by histomorphometric analysis. Results Kruskal-Wallis tests were performed comparing new bone formation via histomorphometric analysis. No statistically significant difference of new bone formation was found between Bio-Oss only, Bio-Oss and PRP, and Bio-Oss and fibrin sealant at 4 and 8 weeks (P>0.05). Conclusion This study fails to find a stimulatory effect of PRP and Fibrin sealant on New bone formation of Bio-Oss grafts by histomorphometric analyses.

Keywords

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