Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Design, Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-1,2,4-triazoles and Their Hydrazino Derivatives

  • Udupi, R.H. (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Sudheendra, Sudheendra (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Bheemachari, Bheemachari (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Srinivasulu, N. (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Varnekar, Rajesh (Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College) ;
  • Purushottamachar, Puranik (Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine)
  • Published : 2007.12.20
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Abstract

3-Aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-mercapto-1,2,4-triazoles (3a1-a14) were prepared starting from potassium dithio carbazinates (2a1-a14). These triazoles were then employed in the synthesis of 3-aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-hydrazino-1,2,4-triazoles (4a1-a14). All the newly synthesized compounds were characterized by analytical, IR, NMR spectral studies. The compounds were screened for their antibacterial, antifungal, anti-inflammatory and analgesic properties. Most of the compounds have shown significant antifungal activity while few have shown excellent anti-inflammatory and analgesic activity. An attempt is made to study the structure activity relationship (SAR).

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References

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