Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
권호 표지

Angiogenic inhibitory effect of Zingiberis Rhizoma

건강(乾薑)의 혈관신생(血管新生) 억제효과(抑制效果)에 관한 연구(硏究)

  • Nam, Sang-Choon (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Kang, Hee (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Shim, Bum-Sang (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Kim, Sung-Hoon (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Choi, Seung-Hoon (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Ahn, Kyoo-Seok (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University, Institute of Oriental Medicine, Kyunghee University)
  • 남상춘 (경희대학교 한의과대학 병리학교실 경희대학교 한의학연구소) ;
  • 강희 (경희대학교 한의과대학 병리학교실 경희대학교 한의학연구소) ;
  • 심범상 (경희대학교 한의과대학 병리학교실 경희대학교 한의학연구소) ;
  • 김성훈 (경희대학교 한의과대학 병리학교실 경희대학교 한의학연구소) ;
  • 최승훈 (경희대학교 한의과대학 병리학교실 경희대학교 한의학연구소) ;
  • 안규석 (경희대학교 한의과대학 병리학교실 경희대학교 한의학연구소)
  • Published : 2006.12.29
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Abstract

This study was conducted to investigate angiogenic inhibitory effect of Zingiberis Rhizoma methanol extract using ECV-304 cells and HT1080 fibrosarcoma cells. The viability of ECV-304 was 30% at 50${\mu}g/m{\ell}$ of Zingiberis extract and that of HT1080 was 30% at 100${\mu}g/m{\ell}$. Using the BrdU incorporation assay, Zingiberis inhibited the DNA synthesis of ECV-304 and HT1080 by 70% and 50 % at 200${\mu}g/m{\ell}$. In tube formation assay, at 10${\mu}g/m{\ell}$ of Zingiberis, tube network began to degrade and at higher doses, it was completely destroyed. Zymography demonstrated that Zingiberis extract decreased MMP-9 at 10${\mu}g/m{\ell}$ and higher doses remarkably inhibited the expression of MMP-9. These data indicate that Zingiberis Rhizoma has angiogenic inhibitory effects and shows the possibility of future anti-metastatic drug.

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