The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Hwangryunhaedoktang on DSS-induced Colitis

황련해독탕이 DSS로 유발된 흰쥐의 궤양성 대장염에 미치는 영향

  • An Joong-Hwan (Department of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Choi En-Young (Department of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee Seong-Hwan (Department of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee Seong-Hwan (Department of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lim Seong-Woo (Department of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 안중환 (동국대학교대학원 한의학과 비계내과학교실) ;
  • 최은영 (동국대학교대학원 한의학과 비계내과학교실) ;
  • 이성환 (동국대학교대학원 한의학과 비계내과학교실) ;
  • 박인식 (동국대학교 한의학과 해부학교실) ;
  • 임성우 (동국대학교대학원 한의학과 비계내과학교실)
  • Published : 2006.06.30
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Abstract

Objectives : We examined the effect of Hwangryunhaedoktang(HH) on the experimental ulcerative colitis induced by dextran sulfate sodium (DSS). Methods : Experimental colitis was induced in rats by daily treatment with 5% DSS in the drinking water for 5 days. Afterward, the mts were divided into two groups: the control group was administered water and the sample group was administered HH for 7 days. Results : The sample group provided HH for 7 days demonstrated fast recovery of body weight compared with the control group. Histologic change showed fast regeneration of crypt and surface epithelial cells and decreased edema of the submucosa and decreased lymphatic follicle of mucosa compared with the control group. Immunohistochemical stain usingCOX-2 gene was decreased and there was localized Ki-67 positive reaction. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by transmission electron microscope. These results indicate therapeutic effect of HH on DSS-induced colitis in rats.

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