The Journal of Traditional Korean Medicine (한국전통의학지)

Korea Bio Medical Science Institute (한국전통의학연구소)
권호 표지

Inhibitory Effects of the Ethanol Extract of Lavandula vera on Sebum Synthesis

라벤더 에탄올 추출물의 피지생성 억제효과

  • Park, Si-Jun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Ho-Min (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Han, Kyu-Soo (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Seong, Geum-Su (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Shin, Mee-Ran (Dept.of Prosthodontics,Hangcred Sacred Heart Hospital,Hallym University Medical Center) ;
  • Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 박시준 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김호민 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 한규수 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 성금수 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 신미란 (한림대학교 한강성심병원 보철학과교실) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2006.12.29
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Abstract

Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95. the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

Keywords