Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Suppressive Effects of Young Radish Cultivated with Sulfur on Growth and Metastasis of B16-F10 Melanoma Cells

  • Kim Soo-Jin (Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan) ;
  • Kim Byung-Sam (Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan) ;
  • Kyung Tae-Wook (Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan) ;
  • Lee Sang-Chul (Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan) ;
  • Rho Chi-Woong (Gyeongsangnam-do Agricultural Research and Extension Service) ;
  • Choi Kyung-Rak (Gyeongsangnam-do Agricultural Research and Extension Service) ;
  • Hwang Hae-Jun (Gyeongsangnam-do Agricultural Research and Extension Service) ;
  • Choi Hye-Seon (Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan)
  • Published : 2006.03.01
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Abstract

The oral administration of extracts of young radishes cultivated with sulfur after intravenous tumor cell injection achieved a marked reduction of pulmonary colonization in mice. Treatment of the mice with extracts of young radish cultivated with sulfur did not show any increase in the number of CD8+ or NK T cells in the spleen, indicating no influence on host immunity. Sulforaphane, which could be a candidate for an active compound from young radishes cultivated with sulfur, inhibited cell growth of B16-F10 melanoma cells. In addition, extracts of the young radish cultivated with sulfur-fed group showed enhanced quinine reductase (QR) activities in the liver and lung and a slight increase of glutathione S-transferase (GST) activity in the liver. These results suggested that the administration of extracts of young radishes cultivated with sulfur suppressed pulmonary tumorigenesis, possibly due to increased activity of detoxification enzymes in the liver and lung, and partly due to cell cytotoxicity.

Keywords

References

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