Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effect of Hemodialysis on Dogs with Acute Renal Failure Induced by Ethylene Glycol

Ethylene Glycol로 유발된 급성신부전증 이환견에 대한 혈액투석효과

  • Cho Hyo-Gueon (College of Veterinary Medicine, Chungnam National University) ;
  • Lee Jung-Yeon (Obihiro University of Agriculture and Veterinary Medicine) ;
  • Liu Jian-Zhu (College of Veterinary Medicine, Chungnam National University) ;
  • Song Kun-Ho (College of Veterinary Medicine, Chungnam National University) ;
  • Park Seong-Jun (College of Veterinary Medicine, Chungnam National University) ;
  • Kim Duck-Hwan (College of Veterinary Medicine, Chungnam National University)
  • Published : 2006.03.01
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Abstract

The aim of this study is to clarify the therapeutic effect of hemodialysis (HD) on acute renal failure in dogs experimentally induced by ethylene glycol (EG) ingestion in experiment 1(HD on 12 and 36 hours after EG injestion) and experiment 2(HD on 24 and 48 hours after EG injestion). Clinical signs such as vomiting, depression, ataxia and knuckling were improved on experiment 1 and 2. White blood cell (WBC) and platelets (PLT) were decreased, and packed cell volume (PCV) was increased after hemodialysis, however, no significant differences were observed in experiment 1 and 2. BUN, creatinine and phosphorus was significantly decreased in experiment 1 and 2, respectively. These results suggested that hemodialysis was effective for acute renal failure in dogs induced by EG ingestion.

Keywords

References

  1. Adams WA, Toal RL, Walker MA, Breider MA. Early renal findings in dogs with experimentally induced ethylene glycol nephrosis. Am J Vet Res 1989; 8: 1370-1376
  2. Beckett SD, Shields RP. Treatment of acute ethylene glycol (antifreeze) toxicosis in the dog. J Am Vet Med Assoc 1971; 158: 472-476
  3. Bey TA, Walter FG;, Gibly RL, James ST, Gharahbaghian L. Survival after ethylene glycol poisoning in a patient with an arterial pH of 6.58. Vet Hum Toxicol 2002; 44: 167-168
  4. Cowgill LD. Application of peritoneal dialysis and hemodialysis in the management of renal failure. In : Canine and feline nephrology and urology. Baltimore: Lee and Febiger, 1995: 573-596
  5. Cowgill LD, Langston CE. Role of hemodialysis in the management of dogs and cats with renal failure. Vet Clin North Am Small Anim Pract 1996; 26: 1347-1378 https://doi.org/10.1016/S0195-5616(96)50132-4
  6. Dial SM, Thrall MH, Hamar DW. Efficacy of 4-methyl-pyrazole for treatment of ethylene glycol intoxication in dogs. Am J Vet Res 1994; 55: 1762-1770
  7. Dial SM, Thrall MH, Hamar DW. Comparison of ethanol and 4-methylpyrazole as treatments for ethylene glycol intoxication in cats. Am J Vet Res 1994; 55: 1771-1782
  8. DiBartola SP, Chew DJ, Tarr MJ, Sams RA. Hemodialysis of a dog with acute renal failure. J Am Vet Med Assoc 1985; 15: 1323-1326
  9. Eder F, McGrath CM, Dowdy YG. Ethylene glycol poisoning: Toxicokinetic and analytical factors affecting laboratory diagnosis. Clin Chem 1998; 44: 168-177
  10. Faessel H, Houze P, Baud FJ, Scherrmann JM. 4-methylpyrazole monitoring during hemodialysis of ethylene glycol intoxicated patients. Eur J Clin Pharmacol 1995; 49: 211-213
  11. Finco DR. Applied physiology of the kidney. In: Canine and feline nephrology and urology, Baltimore: Lea and Febiger. 1995: 29-46
  12. Fox LE, Grauer GF, Dubielzig RR, Bjorling DE. Reversal of ethylene glycol induced nephrotoxicosis in a dog. J Am Vet Med Assoc 1987; 191: 1433-1435
  13. Grauer GF, Thrall MA. Ethylene glycol(antifreeze) poisoning in the dog and cat. J Am Vet Med Assoc 1982; 18: 492-497
  14. Grauer GF, Thrall MA, Henre MS, Grauer RM. Early clinicopathologic findings in dogs ingesting ethylene glycol. Am J Vet Res 1984; 45: 2299-2303
  15. Grauer GF, Lane IF. Acute renal failure: Ischemic and chemical nephrosis. In: Canine and feline nephrology and urology. Baltimore: Lea and Febiger. 1995: 441-459
  16. Hylander B, Kjellstrand CM. Prognostic factors and treatment of severe ethylene glycol intoxication. Intensive Care Med 1996; 22: 546-552 https://doi.org/10.1007/BF01708094
  17. Kersting RJ, Nielse Sw. Experimental ethylene glycol poisoning in the dog. Am J Vet Res 1966; 27: 574-582
  18. Nunamaker DM, Medway W, Berg P. Treatment of ethylene glycol poisoning in the dog. J Am Vet Med Assoc 1971; 159: 310-313
  19. Smith BJ, Anderson BG, Smith S, Chew DJ. Early effects of ethylene glycol on the ultrastructure of the renal cortex in dogs. Am J Vet Res 1990; 51: 89-96
  20. Tilley LP, Smith KWK. The 5-minute veterinary consult canine and feline, 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 1999: 680-681
  21. 김지현,이영재,이경갑. 개에서 Gentamycin과 ethylene glycol에 의한 급성신부전의 임상병리학적 진단. 한국임상수의학회지 2000; 17: 327-333
  22. 서울대학교병원신실편. 혈액투석. 서울: 고려의학. 1987: 41-130
  23. 성은주,이현범. Ethylene glycol 중독견의 임상병리학적 소견. 대한수의학회지 1997; 37: 883-897
  24. 연세대학교신장질환연구소편저. 신장학. 서울: 의학문화사. 1999: 861-900
  25. 임상간호사회 신장간호분야편. 투석환자 관리지침. 서울: 고려의학 1994: 1-86
  26. 임상현. 실험적으로 유발한 급성 신부전 개에서 icodextrin 을 이용한 복막투석. 서울대학교 대학원 수의학과 석사학위논문. 2004: 28-29
  27. 한국수의내과학교수협의회. 소동물내과학 진단과 치료. 서울: 신흥메드싸이언스. 2003: 504-512