Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Modifying Effect of Bisphenol A on the Preneoplastic and Neoplastic Lesions of Rat Liver Treated with Diethylnitrosamine Infusion

화학적 간발암모델에서 Bisphenol A가 간암의 전암성 및 종양성 병변에 미치는 영향

  • Park, Ki-Dae (National Institute of Toxicological Research, Korea Food & Drug Administration) ;
  • Han, Beom-Seok (National Institute of Toxicological Research, Korea Food & Drug Administration) ;
  • Rhim, Kook-Hwan (College of Health Sciences, Korea University)
  • 박기대 (식품의약품안전청 국립독성연구원) ;
  • 한범석 (식품의약품안전청 국립독성연구원) ;
  • 임국환 (고려대학교 보건과학대학)
  • Published : 2006.02.01
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Abstract

Bisphenol A(BPA) was known as an endocrine disrupting chemical. This study was conducted to assess the effect of BPA, weaker estrogen, on the preneoplastic and neoplastic lesions induced by diethylnitrosamine (DEN). One hundred male F344 rats were divided into four groups which were treated with DEN followed by BPA. To make liver tumor early, we conducted that DEN containing osmotic pump implanted into rat abdominal cavity. Then diet containing BPA were fed to the rats. All animals were sacrificed at 10 and 18 weeks. Body weights were significantly decreased in 4000ppm at 18 weeks. Relative Liver weights of 4000 ppm BPA treated group were significantly increased compared to that of DEN alone group at 18 weeks. There were no significant differences of liver tumor incidences. Sum area of GST-P positive foci and BrdU labeling indices of BPA treated group were not significantly different compared to those of control group. These results suggest that BPA have no effects in preneoplastic and neoplastic lesions on DEN-induced hepatocarcinogenesis.

Keywords

References

  1. Caroline, M. M., Enrique, H. L., Monica, M. T., Carlos, S. and Ana, M. S. : In Utero Exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biology of Reproduction, 65, 1215-1223, 2001 https://doi.org/10.1093/biolreprod/65.4.1215
  2. Gould, J. C., Leonard, L. S., Maness, S. C, Wagner, B. L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D. P. and Gaido, K. W. : Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Molecular and Cellular Endocrinology, 142, 203-214, 1998 https://doi.org/10.1016/S0303-7207(98)00084-7
  3. Nakagawa, Y. and Suzuki, T. : Metabolism fo bisphenol A in isolated rat hepatocytes and oestrogenic activity of a hydroxylated metabolite in MCF-7 human breat cancer cells. Xenobiotica, 31(3), 113-123, 2001 https://doi.org/10.1080/00498250110040501
  4. Busch, F. X., Ribes, J. and Borras, J. : Epidemiology of primary liver cancer. Semin Liver Dis., 19, 271-285, 1999 https://doi.org/10.1055/s-2007-1007117
  5. Yu, M. C., Yuan, J. M., Govindarajan, S. and Ross, R. K. : Epidemiology of hepatocellular carcinoma. Can. Gastroenterol., 14, 703-709, 2000 https://doi.org/10.1155/2000/371801
  6. Lui, W. Y., Lin, H. L., Chau, G. Y., Liu, T. Y. and Chi, C. W. : Male predominance in hepatocellular carcinoma: new insight and a possible therapeutic alternative. Med. Hypotlzeses, 55(4), 348-350, 2000 https://doi.org/10.1054/mehy.2000.1066
  7. International agency of research on cancer. Cancer incidence in five continents volume VII. Lyon: IARC, 1997
  8. Sawaki, M., Enomoto, K., Takahashi, H., Nakajima, Y. and Mori, M. : Phonotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats. Carcinogenesis, 11, 1857-1861, 1990 https://doi.org/10.1093/carcin/11.10.1857
  9. Kemp, C. J. and Drinkwater, N. R. : Genetic variation in liver tumor susceptibility. plasma testosterone levels, and androgen receptor binding in six inbred strains of mice. Cancer Res., 49, 5044-5047, 1989
  10. Ahn, B., Han, B. S., Kim, D. J. and Ohshima, H. : Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. Carcinogenesis, 20(7), 1337-1344, 1999 https://doi.org/10.1093/carcin/20.7.1337
  11. Pitot, H. C., Dragan, Y. P., Teeguarden, J., Hsia, S. and Campbell, H. : Quantitation of multistage carcinogenesis in rat liver. Toxicol. Pathol., 24(1), 119-128, 1996 https://doi.org/10.1177/019262339602400116
  12. Stewart, S. : Cellular origin of hepatocellular carcinomas. Cell & Developental Biology, 13, 419-424, 2002 https://doi.org/10.1016/S1084952102001295
  13. Birner, P., Ritzi, M., Musahl, C., Knippers, R., Gerdes, J., Voigtlander, T., Budka, H. and Hainfellner, J. A. : Immunohistochemical detection of cell growth fraction in formalin-fixed and paraffin-embedded murine tissue. Am. J. Pathol., 158(6), 1991-1996, 2001 https://doi.org/10.1016/S0002-9440(10)64670-6
  14. Bosq, J. and Bourhis, J. : Bromodeoxyuridine (BrdU). Analysis of cellular proliferation. Ann. Pathol., 17(3), 171-178, 1997
  15. Ishida, H., Iwama, T., Yoshinaga, K., Gonda, T. and Idezuki, Y. : Bodeoxyu-ridine uptake by early liver metastases in rats: a comparison of the hepatic artery and portal vein infusion routes. Surg. Today, 28(8), 822-829, 1998 https://doi.org/10.1007/s005950050234
  16. Ahel, M., McEvoy, J. and Giger, W. : Bioaccumulation of the lipophilic metabolites of moninic surfactants in freshwater organisms. Environ Pollut., 79, 243-249, 1999
  17. Lee, P. C. : Disruption of male reproductive tract development by administration of the xenoestrogen, nonylpheonl, to male newborn rat. Endocrine, 9, 105-111, 1998 https://doi.org/10.1385/ENDO:9:1:105
  18. De Jager, C., Bornman, M. S., Wandrag, S. and van der Horst, G. : Effect of p-nonylphenol, an environmental toxicant with oestrogenic properties, on fertility potentiall in adult male rats after gestational, lactational and direct exposure. Andrologia, 31, 107-113, 1999 https://doi.org/10.1046/j.1439-0272.1999.00246.x
  19. Busch, F. X., Ribes, J. and Borras, J. : Epidemiology of primary liver cancer. Semin Liver Dis., 19, 271-285, 1999 https://doi.org/10.1055/s-2007-1007117
  20. Yeo, M. K. : Effects of bisphenol A and nonylphenol on zebrafish embryogenesis. Korean Journal of Environmental Health, 29(5), 1-9, 2003
  21. Choi, K., Hwang, S. H., Kwon, E. and Kim, P. G. : The reproductive toxicity by combined treatment of bisphenol A and butyl benzyl phthalate during gestation, lactation period in rats. Korean Journal of Environmental Health, 30(2), 71-78, 2004
  22. Kim, Y. J. : Reaction conditions for laccase catalyzed degradation of bisphenol A. Korean Journal of Environmental Health, 30(2), 79-83, 2004
  23. Kim, P. G., Lee, N. R. and Hwang, S. H. : The bisphenol A : A modulator of pregnancy in rats. Korean Journal of Environmental Health, 29(4), 27-34, 2003