생물정신의학 (Korean Journal of Biological Psychiatry)
- 제13권3호
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- Pages.191-201
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- 2006
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
정신분열병 환자에서 인지기능 및 정신병적 증상의 상관관계
Correlation between Cognitive Functions and Psychotic Symptoms in Schizophrenic Patients
- 김용구 (고려대학교 의과대학 안산병원 정신과학교실) ;
- 이정애 (고려대학교 의과대학 안산병원 정신과학교실) ;
- 이소연 (고려대학교 의과대학 안산병원 정신과학교실) ;
- 이분희 (고려대학교 의과대학 안산병원 정신과학교실) ;
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한창수
(고려대학교 의과대학 안산병원 정신과학교실)
- Kim, Yong-Ku (Department of Psychiatry, College of Medicine, Korea University Ansan Hospital) ;
- Lee, Jung-Ae (Department of Psychiatry, College of Medicine, Korea University Ansan Hospital) ;
- Lee, So-Youn (Department of Psychiatry, College of Medicine, Korea University Ansan Hospital) ;
- Lee, Bun-Hee (Department of Psychiatry, College of Medicine, Korea University Ansan Hospital) ;
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Han, Chang-Su
(Department of Psychiatry, College of Medicine, Korea University Ansan Hospital)
- 발행 : 2006.08.31
초록
Objectives : The purpose of this study was to investigate whether the cognitive functions would be correlated with psychotic symptoms and whether antipsychotic treatments would affect the cognitive functions after 8 weeks. Methods : The thirty-five schizophrenic patients were conducted in this study. The psychopathology was measured using PANSS. The memory function, executive function, and sustained attention were measured using Memory Assessment Scale(MAS), Wisconsin Card Sorting Test(WCST), and Vigilance(VIG) and Cognitrone(COG) in Vienna Test System. After 8 weeks of antipsychotic treatment, we retested the cognitive tests. Results : 1) The cognitive tests after the 8 week's treatment showed significant improvements in memory and executive function in the schizophrenic patients. On the other side, sustained attention did not show improvement. 2) The change of PANSS were correlated with perseverative response, perseverative error and total correct in WCST at baseline. WCST scores at baseline were correlated with negative symptoms, but not positive ones. Conclusion : These study suggests that 1) the impaired sustained attention could be a vulnerability marker in schizophrenia, 2) memory & executive function deficit could be reversible after treatment, and 3) medication might have a benefit in improving the cognitive functions in schizophrenia. Furthermore, the data supports that the better premorbid executive function was, the more favorable was the treatment response in schizophrenic patients. Finally, this study indicates that executive function might be an index of treatment improvement.
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