Valproic Acid Effect in Nerve Regeneration Using Gore-Tex® Tube Filled with Skeletal Muscle

골격근섬유로 채워진 Gore-Tex® 도관을 이용한 신경재생에 있어서 Valproic Acid의 효과

  • Kang, Nak Heon (Department of Plastic & Reconstructive Surgery, College of Medicine, Chungnam National University) ;
  • Oh, Hyeon Bae (Department of Plastic & Reconstructive Surgery, College of Medicine, Chungnam National University) ;
  • Lee, Ki Ho (Department of Plastic & Reconstructive Surgery, College of Medicine, Chungnam National University) ;
  • Kim, Jong Gu (Department of Plastic & Reconstructive Surgery, Eulji Medical College)
  • 강낙헌 (충남대학교 의과대학 성형외과학교실) ;
  • 오현배 (충남대학교 의과대학 성형외과학교실) ;
  • 이기호 (충남대학교 의과대학 성형외과학교실) ;
  • 김종구 (을지대학교 의과대학 성형외과학교실)
  • Received : 2005.11.25
  • Published : 2006.03.10

Abstract

As the large defect of peripheral nerve occurs, the autologous nerve graft is the most ideal method but it has many limitations due to donor site morbidities. Various materials have been developed for the nerve defect as the conduits, but none of these materials is satisfactory. Among them, $Gore-Tex^{(R)}$ tube seems to be one of the most ideal nerve conduit materials at peripheral nerve defect. Many researches have focused on finding the neurotrophic factors. It is recently demonstrated that Valproic acid(VPA) has an effect of axonal regeneration as a neurotrophic factor without enzymatic degradation and toxicity problems. The purpose of this study is to evaluate the effect of VPA on the nerve regeneration at the peripheral nerve defect. A 10 mm gap of rat sciatic nerve was made and $Gore-Tex^{(R)}$ tube filled with biceps femoris muscle was placed at the nerve defect site. We let the rat take VPA as drinking water in experimental group and did not give VPA to the control group. We estimated the results as electrophysiologic and histological aspects for 16 weeks after the surgery. The nerve conduction velocity, total myelinated axon count, myelin sheath thickness and mean nerve fiber diameter significantly increased in VPA-treated experimental group when compared to the control (p < 0.05). From the above results, we conclude that VPA promotes the nerve regeneration at the peripheral nerve defect site. It is suggested that $Gore-Tex^{(R)}$ tube filled with skeletal muscle and VPA administration may be a good substitute for autologous nerve graft.

Keywords

References

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