Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Effects of Occupational Chromium Exposure on Plasma Homocysteine, Folate and Vitamin B12 Concentration

직업적인 크롬 노출이 혈중 Homocysteine, Folate와 Vitamin B12 농도에 미치는 영향

  • Kim, Ki-Woong (Occupational Safety and Health Research Institute, KOSHA) ;
  • Kim, Kyoo Sang (Occupational Safety and Health Research Institute, KOSHA) ;
  • Park, Injeong (Occupational Safety and Health Research Institute, KOSHA) ;
  • Kang, Seong-Kyu (Occupational Safety and Health Research Institute, KOSHA) ;
  • Oh, Sung-Soo (Occupational Safety and Health Research Institute, KOSHA) ;
  • Jeong, Hyo Seok (Dept. of Chemistry, Collage of Natural Science, Soonchunhyang University) ;
  • Chang, Sung Keun (Dept. of Chemistry, Collage of Natural Science, Soonchunhyang University)
  • 김기웅 (한국산업안전공단산업안전보건연구원) ;
  • 김규상 (한국산업안전공단산업안전보건연구원) ;
  • 박인정 (한국산업안전공단산업안전보건연구원) ;
  • 강성규 (한국산업안전공단산업안전보건연구원) ;
  • 오성수 (한국산업안전공단산업안전보건연구원) ;
  • 정효석 (순천향대학교자연과학대학화학과) ;
  • 장성근 (순천향대학교자연과학대학화학과)
  • Received : 2006.03.03
  • Accepted : 2006.08.20
  • Published : 2006.09.30
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Abstract

We evaluated the relations among exposure and urinary levels of Cr, folate, vitamin $B_{12}$ and Hcy levels in the workers chronically exposure to Cr. Subjects were 104 male employees, 65 workers exposed to Cr in 9 electroplating plants and 39 office workers who had never been occupationally exposed to hazardous substances including Cr. The geometric mean(GM) of Cr in workplace was $0.069{\pm}0.101mg/m^3$ and urinary Cr was $0.483{\pm}0.394mg/g$ creatinine and airborne Cr concentration was significantly correlated to the urinary concentration of Cr(r=0.900, p=0.000). The geometric mean concentration of urinary Cr in control group was $0.301{\pm}0.255mg/g$ creatinine. In comparing the workers exposed to Cr with controls, significantly higher mean plasma levels were found of Hcy($11.3{\pm}4.9$ vs $9.4{\pm}4.7{\mu}mol/{\ell}$, p=0.05), but vitamin $B_{12}$ levels ($181.8{\pm}68.7$ vs $216.0{\pm}64.3nmol/{\ell}$, p=0.01) was significantly decreased. Hcy concentrations correlated positively with airborne Cr concentrations(r=0.287, p=0.004) and urinary Cr concentrations(r=0.244, p=0.015) but folate concentrations correlated negatively with airborne(r=-0.234, p=0.020) and urinary Cr concentrations(r=-0.640, p=0.090), respectively. No correlations were observed between vitamin $B_{12}$, airborne and urinary Cr concentrations. Also, Hcy concentrations correlated positively with vitamin $B_{12}$(r=0.295, p=0.0020 and negatively with folate concentrations(r=-0.196, p=0.046). The various biological(i.e. age and serum indicates) or lifestyle factors(i.e. medication, smoking, alcohol and coffee intake), also taken into account as potential confounders, did not influence the correlations found. Thus, this study found evidence that Cr might be associated with elevated plasma levels of Hcy. Furthermore, elevated plasma levels of Hcy were significantly associated with folate and vitamin $B_{12}$ concentration.

Keywords

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