Food Science and Biotechnology

  • 제15권3호
  • /
  • Pages.363-368
  • /
  • 2006
  • /
  • 1226-7708(pISSN)
  • /
  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

Inhibitory Effects of Ulmus parvifolia and Liriope platyphylla Wang et Tang on Histamine Release from Rat Peritoneal Mast Cells

  • Yang, Su-Ok (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Ji, Geun-Eog (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University)
  • 발행 : 2006.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Twenty-four different natural food materials extracted with 80% methanol were used to investigate the inhibition of cell-mediated immediate type allergic reactions induced by compound 48/80 in rat peritoneal mast cells (RPMCs). Nine 80% methanol extracts screened at a concentration of $10\;{\mu}g/mL$ inhibited histamine release from RPMCs induced by compound 48/80. Of these, two materials (Ulmus parvifolia and Liriope platyphylla Wang et Tang) were extracted and fractionated into four different solvent types (chloroform, ethylacetate, butanol, and water), and the fractions with major anti-allergic effects were assessed. The chloroform fraction of U. parvifolia (UP) at $5\;{\mu}g/mL$ and the ethylacetate fraction of L. platyphylla Wang et Tang (LPWT) at $1\;{\mu}g/mL$ showed the greatest inhibition of histamine release induced by compound 48/80. The chloroform fraction of UP and the ethylacetate fraction of LPWT in combination showed a greater inhibition of histamine release than either fraction alone. The cAMP levels in RPMCs treated with UP and LPWT were significantly greater than in cells treated with compound 48/80 alone. Our studies suggest that extracts from UP and LPWT may alleviate immediate type hypersensitivity reactions through the increase of cAMP levels in the mast cells.

키워드

참고문헌

  1. Joseph A, Bellanti MD. Immunology. Asian edition. W. B. Saunders Company. Philadelphia, PA, USA. pp. 184-227 (1971)
  2. Eli B, Richard C, Geoffrey S. Immunology: a short course. 4th ed. New York, NY, USA. pp. 279-288 (2000)
  3. Puxeddu I, Piliponsky AM, Bachelet I, Levi-Schaffer F. Mast cells in allergy and beyond. Int. J. Biochem. 35: 1601-1607 (2003) https://doi.org/10.1016/S1357-2725(03)00208-5
  4. Makino H, Saijo T, Ashida Y, Kuriki H, Maki Y. Mechanism of action of an antiallergic agent, Amlexanox (AA-673), in inhibiting histamine release from mast cells. Int. Arch. Allergy Appl. Immunol. 82: 66-71 (1987) https://doi.org/10.1159/000234292
  5. Timothy JS, Keith LP, William S, Charles WP. Modulation of cyclic AMP in purified rat mast cells. I. Responses to pharmacologic, metabolic, and physical stimuli. J. Immunol. 114: 1473-1479 (1975)
  6. Richard AG, Thomas JK, Barbara AO, Janis K. Immunology. W. H. Freeman and Company. New York, NY, USA. pp. 361-378 (2002)
  7. Ahmed C, Marc M, Yves L. Substance P-related inhibitors of mast cell exocytosis act on G-proteins or on the cell surtace. Eur. J. Pharmacol. 341: 329-335 (1998) https://doi.org/10.1016/S0014-2999(97)01480-5
  8. Behzad EK, Marc M, Christian B, Yves L. Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli. Eur. J. Pharmacol. 272: 97-102 (1995) https://doi.org/10.1016/0014-2999(94)00628-K
  9. Mouli M, Bronner C, Bochaert J, Rouot B, Yves L. Interaction of substance P, compound 48/80 and mastoparan with the a-subunit C-terminus of G protein. Immunol. Lett. 25: 355-357 (1990) https://doi.org/10.1016/0165-2478(90)90207-7
  10. Michaela RR, Melissa AB. The role of mast cells in allergy and autoimmunity. Curr. Opin. Immunol. 14: 728-733 (2002) https://doi.org/10.1016/S0952-7915(02)00394-1
  11. Mouli M, Bronner C, Bueb J-L, Tschirhart E, Gies J-p, Landry Y. Activation of rat peritoneal mast cells by substance P and mastoparan. J. Pharmacol. Exp. Ther. 250: 329-235 (1989)
  12. Tasaka K, Mio M, Okamoto M. Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy 56: 464-469 (1986)
  13. M, Hugli TE, Landry Y, Bronner C. Peptidergic pathway in human skin and rat peritoneal mast cell activation. Immunopharmacology 27: 1-11 (1994) https://doi.org/10.1016/0162-3109(94)90002-7
  14. Kim HM, Lee EH, Cho HH, Moon YH. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by spirulina. Biochem. Pharmacal. 55: 1071-1076 (1998) https://doi.org/10.1016/S0006-2952(97)00678-3
  15. Moon JH, Om AS, Kwon HS, Kim YJ, Ji GE. Fermented product development of Cynanchum wilfordii Hemsley by lactic acid bacteria and bifidobacteria. Food Sci. Biotechnol. 13: 285-288 (2004)
  16. S, Gong J, Liu F, Mohammed U. Naturally occurring polyphenolic antioxidants modulate IgE-mediated mast cell activation. Immunology 100: 471-480 (2000) https://doi.org/10.1046/j.1365-2567.2000.00045.x
  17. Shetler I, Sagi-Eisenberg R. Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release. J. Immunol. 167: 475-81 (2001) https://doi.org/10.4049/jimmunol.167.1.475
  18. Seo CH, Park DI. The effects of Kami-makmmundong-Tang on the respiratory patterns and tracheal tissues in allergic asthma. Dept. of Oriental Medicine, Graduate School, Dong Eui University 12: 19-31 (2000)
  19. Madeleine E, Frederick LP, Peter MW. Some studies on the release of histamine from mast cells stimulated with polylysine. Brit. J. Pharmacol. 70: 329-334 (1980) https://doi.org/10.1111/j.1476-5381.1980.tb07940.x
  20. Kerem MV, Hui L, Mehmet CO, David JP. Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model. Ann. Thorac. Surg. 69: 228-232 (2000) https://doi.org/10.1016/S0003-4975(99)01052-8